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Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 1.
Neurofibromatosis type 1 (NF1) is a common cancer predisposition syndrome caused by mutations in the tumor suppressor gene. encodes neurofibromin, a GTPase-activating protein for RAS proto-oncogene GTPase (RAS). Plexiform neurofibromas ar…