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Exploratory analysis of the human breast DNA methylation profile upon soymilk exposure.
Upon soy consumption, isoflavone metabolites attain bioactive concentrations in breast tissue possibly affecting health. Though in vitro epigenetic activity of soy metabolites has been described, the in vivo impact on the epigenome is large…
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The serum estradiol concentration is the main determinant of the estradiol concentration in normal breast tissue.
[BACKGROUND] The estrogen concentration has been determined in breast tissue, focusing largely on samples obtained from breast cancers. In this study, estradiol concentration was determined in normal breast tissue obtained from women underg…
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Disposition of soy isoflavones in normal human breast tissue.
[BACKGROUND] Despite decades of research on the relation between soy and breast cancer, questions regarding the absorption, metabolism, and distribution of isoflavones in breast tissue largely remain unanswered. [OBJECTIVE] We evaluated th…
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Disposition of hop prenylflavonoids in human breast tissue.
Hop-derived products may contain xanthohumol (XN), isoxanthohumol (IX), and the potent phytoestrogen 8-prenylnaringenin (8-PN). To evaluate the potential health effects of these prenylflavonoids on breast tissue, their concentration, nature…