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Efficacy and Safety of DaxibotulinumtoxinA for Injection in Cervical Dystonia: ASPEN-1 Phase 3 Randomized Controlled Trial.
[BACKGROUND AND OBJECTIVES] ASPEN-1 was a phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy, duration of response, and safety of 2 doses of DaxibotulinumtoxinA for Injection (DAXI), a novel botulinum toxin…
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Reliability, feasibility and satisfaction of telemedicine evaluations for cervical dystonia.
[INTRODUCTION] Telemedicine is used successfully for evaluating patients with neurologic diseases, but has not been tested in cervical dystonia (CD). CD is uniquely suited for telemedicine as the scales validated to assess its severity rely…
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Dystonia: Then and now.
[INTRODUCTION] Dystonia is a rare disorder that has undergone extensive scientific investigation leading to a transformation of understanding over the past century. [METHODS] This manuscript was prepared through a review of relevant litera…
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Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?
[BACKGROUND] Numerous studies have established botulinum toxin (BoNT) to be safe and effective for the treatment of cervical dystonia (CD). Despite its well-documented efficacy, there has been growing awareness that a significant proportion…
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Systematic review of botulinum toxin treatment for oromandibular dystonia.
Oromandibular dystonia (OMD) is an isolated focal dystonia that affects the muscles of the jaw, lower face and tongue. It is a rare disorder but is associated with significant impairment in quality of life. Treatment with oral medications h…
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Multicenter observational study of abobotulinumtoxinA neurotoxin in cervical dystonia: The ANCHOR-CD registry.
[BACKGROUND] The ANCHOR-CD prospective observational registry study evaluated the effectiveness of abobotulinumtoxinA in adult idiopathic cervical dystonia (CD) in clinical practice. [METHODS] Adults with CD were eligible. Treating physici…
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Botulinum Toxin Treatment of Cervical Dystonia.
The use of botulinum toxin for the treatment of cervical dystonia (CD) was first reported in 1985. Since then, four commercially available formulations have been approved by the U.S. Food and Drug Administration for use in CD, including thr…