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32건 · 최신순-
Analysis of osteotomy distance and other predictors of osseous union following mandibular reconstruction with fibula free flap.
[OBJECTIVES] Optimal contouring of fibula free flaps (FFF) for mandibulectomy often requires osteotomies. This study aimed to define criteria for initial gap width by evaluating whether postoperative gap size and other factors influence lon…
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Microsurgery Versus Embolization for Spinal Cord Arteriovenous Malformations: A Proposed Grading System.
[BACKGROUND AND OBJECTIVES] Comparing microsurgery and embolization for spinal cord arteriovenous malformations (SCAVMs) is challenging because of the disease's rarity and the highly heterogeneous angioarchitecture. The aim of this study wa…
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Theacrine protects vascular endothelial cells against oxidative damage after ischemic stroke by inhibiting Rac1 and activating Nrf2 pathway.
Ischemic stroke is a leading global health issue without a definitive treatment. Theacrine (TC), a purine alkaloid extracted from Chinese tea kucha (Camellia assamica var. kucha), has shown potential in brain health and is under investigati…
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Botulinum Toxin Type A in the Treatment of Primary Axillary Hyperhidrosis:A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Efficacy and Safety in Chinese Patients.
[BACKGROUND] The efficacy and safety of botulinum toxin type A (BoNTA) treatment for primary axillary hyperhidrosis (PAH) have not been explored in the Chinese population. [OBJECTIVES] The objective was to evaluate efficacy and safety of 1…
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Endoscopic-assisted removal of injectable Amazingel with or without immediate prepectoral implant-based breast augmentation: safety and aesthetic outcomes from a retrospective study.
[BACKGROUND] Polyacrylamide hydrogel, commercially referred to as Amazingel, was prohibited for use in China in 2006 owing to its associated high complication rates. Conventional techniques for its removal are frequently insufficient to ach…
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Prepectoral versus Subpectoral Dual-Plane Direct-to-Implant Breast Reconstruction with the TiLoop Bra: A Single-Center Prospective Cohort Study.
[BACKGROUND] Advancements in surgical techniques and materials have increased the use of direct-to-implant breast reconstruction after mastectomy. However, the optimal implant placement remains debated, with limited prospective studies comp…
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Analysis of the Surgical Efficacy and Risk Factors of a One-stage Unilateral Approach for Clipping Bilateral MCA Mirror Aneurysms.
[BACKGROUND] Numerous microsurgical approaches are available for treating middle cerebral artery (MCA) mirror aneurysms. However, a definitive conclusion regarding which approach yields the best outcome has yet to be reached. [METHODS] Thi…
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Comparing Outcomes of Pedicled Submandibular Gland Flap and Submental Artery Perforator Flap in Oral Cavity Reconstruction.
[OBJECTIVE] Submandibular gland flap (SMGF) has demonstrated reliability in repairing small- to medium-sized defects, yet it has not gained widespread international adoption. This study aimed to evaluate the efficacy and outcomes of SMGF fo…
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A Retrospective Analysis of Positional and Dimensional Changes in Temporomandibular Joint Following Mandibular Reconstruction With Fibula Flap and Influencing Factors Behind.
[OBJECTIVES] Stable condyle positioning is crucial for temporomandibular joint (TMJ) function, but its long-term stability in patients undergoing segmental mandibulectomy with free fibular flap (FFF) reconstruction is unclear. This study ai…
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Recombinant Detoxified Holotoxin as a Potent Candidate Vaccine Against Botulism.
Vaccination may represent a suitable strategy for preventing botulism. The recombinant expression of toxin functional domains can induce effective immune responses against botulism. This study aims to develop a safe and effective recombinan…
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Efficacy and Safety of Botulinum Toxin Type A in Primary Axillary Hyperhidrosis: A Meta-analysis and Systematic Review.
[BACKGROUND] The clinical efficacy of botulinum toxin type A (BTX-A) injections for the treatment in primary axillary hyperhidrosis is a subject of ongoing debate. This study aims to consolidate and analyze the available evidence regarding …
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Efficacy and Safety of Autologous Follicular Unit Excision in Pediatric Secondary Cicatricial Alopecia: A Retrospective Case Series.
[OBJECTIVE] To explore the efficacy of Follicular Unit Excision (FUE) in treating pediatric secondary cicatricial alopecia. [METHODS] We selected 11 cases of patients under 18 years old who underwent treatment for secondary cicatricial alo…
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The value of radiographic features in predicting postoperative facial nerve function in vestibular schwannoma patients: A retrospective study and nomogram analysis.
[OBJECTIVE] The purpose of this study was to identify significant prognostic factors associated with facial paralysis after vestibular schwannoma (VS) surgery and develop a novel nomogram for predicting facial nerve (FN) outcomes. [METHODS…
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Predicting intraoperative major blood loss in microsurgery for brain arteriovenous malformations.
[OBJECTIVE] Intraoperative blood loss poses a great challenge for brain arteriovenous malformation (AVM) microsurgery, although systematic researches are still lacking. This study aimed to identify factors predicting intraoperative major bl…
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[Effectiveness comparison of endoscopic removal of injectable Amazingel with/without immediate prepectoral implant-based breast augmentation].
[OBJECTIVE] To explore the surgical technique and preliminary safety and aesthetic results of endoscopic removal of injectable Amazingel with/without immediate prepectoral implant-based breast augmentation for patients. [METHODS] The clini…
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Application of delayed extubation for the free-flap reconstruction of oral and maxillofacial defects in patient with oral diseases.
Tracheostomy and delayed extubation (DE) are two methods for managing patients' airways postoperatively after oral and maxillofacial free flap transplantation. We aimed to determine the safety of both the tracheostomy and DE by conducting a…
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Injectable hyperbranched PEG crosslinked hyaluronan hydrogel microparticles containing mir-99a-3p modified subcutaneous ADSCs-derived exosomes was beneficial for long-term treatment of osteoarthritis.
Exosomes (Exos) secreted by adipose-derived stem cells (ADSCs) have shown potential in alleviating osteoarthritis (OA). Previous studies indicated that infrapatellar fat pad (IPFP) derived stem cells (IPFSCs) may be more suitable for the tr…
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Short-term safety and cosmetic outcomes of endoscopic direct-to-implant breast reconstruction and simultaneous contralateral breast augmentation for breast cancer: a prospective analysis of 33 patients.
[BACKGROUND] For patients with small breasts, breast-conserving surgery (BCS) and unilateral nipple-/skin-sparing mastectomy (N/SSM) with breast reconstruction may result in visible breast deformities or asymmetry, and contralateral breast …
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Three-Pedicle Reduction Mammaplasty Technique in the Treatment of Greater Breast Hypertrophy Patients With or Without Breast Cancer: Surgical and Patient-reported outcomes.
[BACKGROUND] Reduction mammoplasty (RM) is an important procedure in the management of symptomatic greater breast hypertrophy with or without early-stage breast cancer. We aim to introduce a new procedure: the three-pedicle reduction mammap…
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Total Mesorectal Excision vs. Transanal Endoscopic Microsurgery Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer: A Multicenter Randomized Trial.
[INTRODUCTION] Transanal endoscopic microsurgery (TEM) is an organ-preserving treatment alternative for patients with early rectal cancer. However, TEM alone is associated with greater risk of local recurrence and inferior survival in compa…
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Techniques and long-term outcomes of Y-shaped autologous dura mater wrap-clipping of blood blister-like aneurysms.
[BACKGROUND] The optimal surgical strategy for treating internal carotid artery (ICA) blood blister-like aneurysms (BBAs) has remained unclear. Wrap-clipping is one of the recommended treatments for BBAs, but the long-term clinical and angi…
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Dynamic muscle paralytic effects of a novel botulinum toxin A free of neurotoxin-associated proteins.
Structurally, botulinum toxin type A (BTX-A) is composed of neurotoxin and nontoxic complexing proteins (CPs), and the neurotoxin has the function of blocking acetylcholine release from the neuromuscular junction and therefore paralyzing mu…
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Botulinum toxin treatment for bielschowsky acquired commitant esotropia in adults.
[BACKGROUND] Many researchers have noticed that there is an increasing trend of Bielschowsky acquired comitant esotropia (ACE) in recent years related to excessive near work, but the exact pathogenesis and treatment methods have not been re…
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Double-Eyelid Blepharoplasty: Dermis-Outer Orbicularis Fascia-Orbicularis-Levator Fixation Technique with Preorbicular Venous Network Preservation.
[BACKGROUND] This article presents a new method using a dermis-outer orbicularis fascia-orbicularis-levator (DOOL) fixation technique for double-eyelid blepharoplasty. [METHODS] Our surgical technique preserves the preorbicular venous netw…
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[Application of three-pedicle reduction mammaplasty in breast cancer patients with moderate or greater breast hypertrophy and/or moderate-to-severe breast ptosis].
[OBJECTIVE] To explore the application and effectiveness of three-pedicle reduction mammoplasty in breast cancer patients with moderate or greater breast hypertrophy and/or moderate-to-severe breast ptosis. [METHODS] The clinical data of 1…
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ASIC1a promotes synovial invasion of rheumatoid arthritis via Ca/Rac1 pathway.
Acid-sensitive ion channels (ASICs) as Ca and Na cation channels are activated by changing in extracellular pH, which expressed in various diseases and participated in underlying pathogenesis. ASIC1a is involved in migration and invasion of…
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A Novel Botulinum Toxin TAT-EGFP-HCS Fusion Protein Capable of Specific Delivery Through the Blood-brain Barrier to the Central Nervous System.
[OBJECTIVE] Botulinum toxin has many applications in the treatment of central diseases, as biological macromolecules, it is difficult to pass through the blood-brain barrier which greatly limits their application. In this paper, we verified…
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Characterization of small GTPase Rac1 and its interaction with PAK1 in crayfish Procambarus clarkii.
Ras-related C3 botulinum toxin substrate 1 (Rac1) participates in many biological processes. In this study, a Rac1 gene was identified in the crayfish Procambarus clarkii with an open reading frame of 579 bp that encoded 192 amino acids. Th…
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Botulinum toxin type A suppresses arterial vasoconstriction by regulating calcium sensitization and the endothelium-dependent endothelial nitric oxide synthase/soluble guanylyl cyclase/cyclic guanosine monophosphate pathway: An study.
[UNLABELLED] Botulinum toxin type A (BTX-A) is a potent neurotoxin that causes relaxation of striated muscle by inhibiting the release of acetylcholine at the neuromuscular junction. Some studies have suggested that BTX-A treatment for Rayn…