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9건 · 최신순-
Impact of botulinum toxin type A on ocular pain with neuropathic features.
[PURPOSE] To investigate the impact of botulinum toxin type A (BoNT-A) on neuropathic/nociplastic ocular pain (NOP) and identify predictors of patient outcomes. [METHODS] A retrospective study of individuals with NOP symptoms (light sensit…
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Navigating the Dry Eye Therapeutic Puzzle: A Mechanism-Based Overview of Current Treatments.
: Dry eye disease (DED) is a multifactorial condition with complex pathophysiology involving tear film instability, ocular surface inflammation, and nerve dysfunction. This review summarizes current evidence on the different available thera…
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Abnormal visual cortex activity using functional magnetic resonance imaging in treatment resistant photophobia in Friedreich Ataxia.
[PURPOSE] Friedreich ataxia (FDRA) is a debilitating neurodegenerative disease that can have ophthalmological manifestations including visual dysfunction, nystagmus, and optic atrophy. However, severe photophobia has not been reported nor e…
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Botulinum toxin A decreases neural activity in pain-related brain regions in individuals with chronic ocular pain and photophobia.
[INTRODUCTION] To examine the effect of botulinum toxin A (BoNT-A) on neural mechanisms underlying pain and photophobia using functional magnetic resonance imaging (fMRI) in individuals with chronic ocular pain. [METHODS] Twelve subjects w…
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Photophobia: shared pathophysiology underlying dry eye disease, migraine and traumatic brain injury leading to central neuroplasticity of the trigeminothalamic pathway.
[BACKGROUND] Photophobia is a potentially debilitating symptom often found in dry eye disease (DE), migraine and traumatic brain injury (TBI). [METHODS] We conducted a review of the literature via a PubMed search of English language articl…
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Alternative therapies for dry eye disease.
[PURPOSE OF REVIEW] Dry eye disease (DED) is a multifactorial disease affecting approximately 5-50% of individuals in various populations. Contributors to DED include, but are not limited to, lacrimal gland hypofunction, meibomian gland dys…
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Periorbital botulinum toxin A improves photophobia and sensations of dryness in patients without migraine: Case series of four patients.
[PURPOSE] Individuals receiving botulinum toxin A (BoNT-A) injections in the head and neck for migraine treatment have reported decreases in photophobia and sensations of dryness, independent of ocular surface parameters. We hypothesized th…
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Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections.
[BACKGROUND] To evaluate the efficacy of botulinum toxin A (BoNT-A) in reducing photophobia and dry eye symptoms in individuals with chronic migraine. Additionally, we aimed to evaluate tear film volume as a potential contributor to symptom…
- Botulinum Toxin A for the Treatment of Photophobia and Dry Eye.