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Increasing the Dose of Onabotulinum Toxin A From 400 to 600 Units for Post-stroke Spasticity: A Retrospective Study on Safety and Muscle Selection.
In Japan, the approved maximum dosage of Onabotulinum Toxin A (BoNT-A) (BOTOX, Allergan plc, Irvine, CA, USA) for upper and lower limb spasticity was increased to 600 units in November 2022. As reports on this high dosage are rare internati…