논문 목록
18건 · 최신순-
Diagnostic accuracy of screening tools for depression and anxiety in cervical dystonia.
[INTRODUCTION] Despite their high prevalence and impact, depression and anxiety are not routinely screened for, and accuracy of screening procedures is unknown in adult-onset dystonia. We evaluated accuracy parameters of selected self-rated…
-
New trends in the treatment of blepharospasm: replacing the standardized approach with a personalized approach.
[INTRODUCTION] Blepharospasm is a type of dystonia associated with overactivity of the orbicularis oculi and nearby muscles causing significant disability. Available treatments are only symptomatic, and many patients experience disability r…
-
An Exploratory, Randomized, Double-Blind Clinical Trial of Dipraglurant for Blepharospasm.
[BACKGROUND] Blepharospasm is treated with botulinum toxin, but obtaining satisfactory results is sometimes challenging. [OBJECTIVE] The aim is to conduct an exploratory trial of oral dipraglurant for blepharospasm. [METHODS] This study w…
-
Can symptoms or signs of cervical dystonia occur without abnormal movements of the head or neck?
[INTRODUCTION] Cervical dystonia is defined by excessive contraction of muscles that produce abnormal postures and movements of the head, neck, and sometimes the shoulders. Many affected individuals also have pain, local muscle hypertrophy,…
-
Duration of botulinum toxin efficacy in cervical dystonia clinical trials: A scoping review.
[INTRODUCTION] Botulinum toxin (BoNT) is first-line treatment for cervical dystonia (CD). Treatment of CD with BoNT usually requires injections every 3-4 months for as long as symptoms persist, which can be for the lifetime of the individua…
-
Pain Reduction in Cervical Dystonia Following Treatment with IncobotulinumtoxinA: A Pooled Analysis.
This analysis pooled pain severity data from four phase 3 and 4 studies of incobotulinumtoxinA (incoBoNT-A) for the treatment of cervical dystonia (CD) in adults. CD-related pain severity was assessed at baseline, each injection visit, and …
-
Proprioceptive Modulation of Pallidal Physiology in Cervical Dystonia.
[BACKGROUND] There is a growing body of evidence suggesting that botulinum toxin can alter proprioceptive feedback and modulate the muscle-spindle output for the treatment of dystonia. However, the mechanism for this modulation remains uncl…
-
An Open-Label Phase 2a Study to Evaluate the Safety and Tolerability of Perampanel in Cervical Dystonia.
[BACKGROUND] Cervical dystonia (CD) is the most common focal isolated dystonia. Preclinical studies report that AMPA-selective glutamate receptor antagonists improve dystonia. Perampanel is a clinically available, AMPA receptor antagonist t…
-
Oromandibular Dystonia: A Clinical Examination of 2,020 Cases.
The goal of this study is to better characterize the phenotypic heterogeneity of oromandibular dystonia (OMD) for the purpose of facilitating early diagnosis. First, we provide a comprehensive summary of the literature encompassing 1,121 c…
-
Medical and Surgical Treatments for Dystonia.
The dystonias are a large and heterogenous group of disorders characterized by excessive muscle contractions leading to abnormal postures and/or repetitive movements. Their clinical manifestations vary widely, and there are many potential c…
-
New approaches to discovering drugs that treat dystonia.
: Dystonia consists of involuntary movements, abnormal posturing, and pain. In adults, dystonia presents in a particular region of the body and causes significant disability due to pain as well as impairment in activities of daily living an…
-
Pharyngeal Dystonia Mimicking Spasmodic Dysphonia.
[OBJECTIVE] The aim of this study was to describe the presentation of pharyngeal dystonia (PD), which can occur as a focal or segmental dystonia with a primarily pharyngeal involvement for the discussion of treatment methods for controlling…
-
Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?
[BACKGROUND] Numerous studies have established botulinum toxin (BoNT) to be safe and effective for the treatment of cervical dystonia (CD). Despite its well-documented efficacy, there has been growing awareness that a significant proportion…
- A strategy for managing flu-like symptoms after botulinum toxin injections.
-
Dystonia treatment: Patterns of medication use in an international cohort.
[OBJECTIVE] To determine the frequency of medication use in patients with dystonia enrolled in an international biorepository study. [METHODS] In a cross-sectional analysis, we included 2,026 participants enrolled at 37 sites in the United…
-
Research Priorities in Limb and Task-Specific Dystonias.
Dystonia, which causes intermittent or sustained abnormal postures and movements, can present in a focal or a generalized manner. In the limbs, focal dystonia can occur in either the upper or lower limbs and may be task-specific causing abn…
-
Comparative effectiveness of propranolol and botulinum for the treatment of essential voice tremor.
[OBJECTIVES/HYPOTHESIS] To assess the comparative effectiveness of botulinum toxin and propranolol in patients with essential vocal tremor (EVT). [STUDY DESIGN] Individual prospective cohort study. [METHODS] Study patients were recruited …
-
Botulinum toxin treatment failures in cervical dystonia: causes, management, and outcomes.
Botulinum toxin (BoNT) is highly effective in the treatment of cervical dystonia (CD), yet a significant proportion of patients report low levels of satisfaction following treatment and fail to follow up for repeated treatments. The goal of…