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Comprehensive Analysis of Free BDPE Content in Commercial Hyaluronic Acid Fillers: Implications for Safety Assessment and Regulatory Standards.
[BACKGROUND] Although manufacturers of 1,4-butanediol diglycidyl ether (BDDE)-cross-linked hyaluronic acid (HA) fillers assert effective removal of unreacted BDDE, the hydrolyzed derivative 3,3'-(butane-1,4-diyl)bis(oxy)bis(propane-1,2-diol…