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Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules.
[INTRODUCTION] Lineage tracing studies in mice have revealed the localization and existence of lineage-restricted mammary epithelial progenitor cells that functionally contribute to expansive growth during puberty and differentiation during…
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Human breast progenitor cell numbers are regulated by WNT and TBX3.
[BACKGROUND] Although human breast development is mediated by hormonal and non-hormonal means, the mechanisms that regulate breast progenitor cell activity remain to be clarified. This limited understanding of breast progenitor cells has be…
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Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells.
Fibroblasts are important in orchestrating various functions necessary for maintaining normal tissue homeostasis as well as promoting malignant tumor growth. Significant evidence indicates that fibroblasts are functionally heterogeneous wit…
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Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines.
[INTRODUCTION] Normal and neoplastic breast tissues are comprised of heterogeneous populations of epithelial cells involving various degrees of maturation and differentiation. While cultured cell lines have been derived from both normal and…
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Reconstruction of human mammary tissues in a mouse model.
Establishing a model system that more accurately recapitulates both normal and neoplastic breast epithelial development in rodents is central to studying human breast carcinogenesis. However, the inability of human breast epithelial cells t…