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Can Intraoperative Cricopharyngeus Muscle Characteristics Be Used to Predict Treatment Success in RCPD?
[OBJECTIVES] To investigate intraoperative findings as predictors for favorable outcomes following Botox injection in patients diagnosed with retrograde cricopharyngeus muscle dysfunction (RCPD). [METHODS] A retrospective review was perfor…
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Assessing the costs of academic engagement in plastic surgery in the United States.
[BACKGROUND] Academic engagement plays a central role in education, leadership development, and career advancement in Plastic Surgery. While other surgical specialties have evaluated the financial barriers to such involvement, plastic surge…
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Reduction of masseter muscle prominence after treatment with onabotulinumtoxinA: Primary results from a randomized phase 2 study.
[BACKGROUND] OnabotA is used to treat masseter muscle prominence (MMP). [OBJECTIVE] To assess the safety and efficacy of OnabotA for MMP in a randomized study. [METHODS] This 12-month, multicenter, double-blind, placebo-controlled, phase …
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Revealing the Patient Perspective: Evolution of Patient-Reported Outcome Measures in Botulinum Toxin Studies in Aesthetic Medicine.
[BACKGROUND] OnabotulinumtoxinA has been licensed for the treatment of upper facial lines for over 20 years. Patient benefits extend well beyond correction of the lines themselves-including positive effects on confidence, self-esteem, feeli…
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Spatiotemporal control of autonomous adipogenesis of pre-adipocyte spheroids by bioactive nanofibers and soft hydrogel microenvironments.
Despite significant clinical utility, current soft tissue reconstruction modalities employing enriched grafts or liposuction impose considerable limitations including volume reduction and donor-site morbidity. Here, we present a biomimetic …
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Race and Ethnicity Independently Predict Adverse Outcomes Following Head and Neck Autograft Surgery.
[OBJECTIVE] There is growing attention toward the implications of race and ethnicity on health disparities within otolaryngology. While race is an established predictor of adverse head and neck oncologic outcomes, there is paucity in the li…
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Trends of female authorship in head and neck surgery publications over the last decade.
[BACKGROUND] While other otolaryngology subspecialties have established female authorship trends, there is no comprehensive study within head and neck surgery (HNS). [METHODS] Five researchers recorded the gender identity of first and seni…
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Racial Disparities in 30 Day Outcomes Following Total Laryngectomy.
[BACKGROUND] Despite the growing literature on racial disparities in the utilization of total laryngectomy (TL), and survival following the treatment of laryngeal cancers, there is a paucity of research in TL cohorts evaluating disparities …
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Safety and tolerability of onabotulinumtoxinA in the treatment of upper facial lines from global registration studies in 5298 participants: A meta-analysis.
[BACKGROUND] Since its discovery as a facial aesthetic treatment >30 years ago, onabotulinumtoxinA has received worldwide approval for dynamic upper facial line treatment. [OBJECTIVE] Meta-analysis examining the safety of onabotulinumtoxin…
- Pyoderma gangrenosum after breast reduction surgery.
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Identifying Public Perceptions, Attitudes, and Concerns about Breast Implants and Their Complications: A National Survey.
[BACKGROUND] Aesthetic and reconstructive implant-based breast operations are among the most common plastic surgery procedures. This study assessed the baseline knowledge of common breast implant-associated complications, and their influenc…
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Reintroducing Flap Reconstruction: One Institution's Safe Return to Flap Surgery during the COVID-19 Pandemic.
[BACKGROUND] Prevention of nosocomial coronavirus disease 2019 (COVID-19) infection for patients undergoing flap-based reconstructive surgery is crucial to providing care and maintaining operative volume and income to support plastic surge…
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Adipose Tissue-Derived Mesenchymal Stem Cell-Derived Exosomes Promote Wound Healing and Tissue Regeneration.
Wound healing is a complex process involving cell proliferation, migration, and extracellular matrix (ECM) remodeling. Extracellular vesicles (EVs) or exosomes derived from adipose tissue-derived stem cells (ASCs) are emerging as promising …
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Treatment of crow's feet lines and forehead lines with Botox (onabotulinumtoxinA): Development, insights, and impact.
Extrinsic and age-related intrinsic factors contribute to the development of facial lines, including lateral canthal lines (called crow's feet lines [CFL]) and horizontal forehead lines (FHL). OnabotulinumtoxinA is a highly effective treatm…
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The Rhytidectomy Scar: Analysis of Patient and Surgeon Perspectives.
An understanding of patient preference is vital for surgeons to create outcomes that align with the goals of patients undergoing cosmetic surgery. This study analyzes the perception of the rhytidectomy scar from the perspective of cosmetic …
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Discrepancies in Gender Representation Between Integrated and Independent Plastic Surgery Programs.
[PURPOSE] Despite increasing female representation in integrated plastic surgery training programs, independent programs have lower representation and slow improvement in female enrollment. Self-reported resident data were used to investiga…
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50% effective concentration of sevoflurane for immobility in cerebral palsy children undergoing botulinum toxin injection.
[BACKGROUND] This prospective study aimed to determine the optimum end-tidal sevoflurane concentration required for immobility during botulinum toxin injection in spontaneously breathing children with cerebral palsy (CP). [METHODS] Twenty-…
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An analysis of factors that influence patient preference of third-line therapy for overactive bladder.
[OBJECTIVE] Patients with overactive bladder (OAB) refractory to first- and second-line therapy may pursue third-line therapies, including intradetrusor onabotulinum toxin-A (BTX), peripheral tibial nerve stimulation (PTNS), and sacral neur…
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A Systematic Review on the Implementation and Educational Value of Resident Aesthetic Clinics.
[BACKGROUND] Resident aesthetic clinics (RACs) provide plastic surgery residents with hands-on aesthetic surgery training. Although RACs have demonstrated successful surgical outcomes without compromising patient care, few studies have eval…
- Reply: Public Perceptions on Breast Implant-Associated Anaplastic Large Cell Lymphoma.
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Thinking Outside the Black Box: Current Perceptions on Breast Implant Safety and Utility.
[BACKGROUND] There is growing public concern surrounding breast implant safety. In fact, the U.S. Food and Drug Administration recently proposed changes to breast implant labeling, which include a boxed warning. Given such efforts to increa…
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Reconstructive and restorative cues improve public perception on the value of plastic and reconstructive surgeries.
[BACKGROUND] Persistent public misconceptions of plastic and reconstructive surgery (PRS), ambiguity between cosmetic versus reconstructive surgical procedures, and subjective interpretation of aesthetics can result in undervaluing of the f…
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A New Decade for Diversity: Trends in Representation of Women at the Northeastern Society of Plastic Surgeons.
[BACKGROUND] In 2018, the Northeastern Society of Plastic Surgeons first Women in Plastic Surgery was established, reflecting the national trend to address the gender gap between men and women in surgery. Conferences, such as the annual NES…
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Public Perceptions on Breast Implant-Associated Anaplastic Large Cell Lymphoma.
[BACKGROUND] Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has entered the spotlight, as several high-profile media outlets have begun to relay the evolving science to the public. This study aimed to gauge the baseline…
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Long-term efficacy and safety of a new botulinum toxin type A preparation in mouse gastrocnemius muscle.
A new type A botulinum toxin (BoNT/A) preparation, JTM201 (NCBI chromosomal DNA ID: CP046450), has been developed, which comprises 900-kDa complexed toxin purified from Clostridium botulinum (strain: NCTC13319), but its safety and efficacy …
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Breast Augmentation in the Transfemale Patient: Comprehensive Principles for Planning and Obtaining Ideal Results.
[BACKGROUND] A growing number of transgender women present to plastic surgeons seeking breast augmentation. Despite some advocating their technical similarity, the authors have found substantially different planning and techniques are neede…
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A comparison study of prabotulinumtoxinA vs onabotulinumtoxinA in myostatin-deficient mice with muscle hypertrophy.
Botulinum toxin A (BoNT-A) is used clinically for various muscle disorders and acts by preventing the release of the neurotransmitter acetylcholine into the synapse space. Here, we compared the efficacy of prabotulinumtoxinA (PRA) and onabo…
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Validity of bispectral index monitoring during deep sedation in children with spastic cerebral palsy undergoing injection of botulinum toxin.
[BACKGROUND] This prospective study aimed to determine whether the bispectral index (BIS) is a valid objective tool for differentiating adequate from inadequate deep sedation in spontaneously breathing children with cerebral palsy (CP). [M…
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OnabotulinumtoxinA (Botox) in the Treatment of Crow's Feet Lines in Japanese Subjects.
[BACKGROUND] This study evaluated the safety and efficacy of onabotulinumtoxinA in Japanese subjects with crow's feet lines (CFL). [METHODS] This phase 3, multicenter, double-blind, randomized study included 2 treatment periods: 6-month pl…
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The male facelift: considerations and techniques.
Facelift in the male patient presents unique challenges with respect to maintenance of normal hairline and management of bearded skin. With careful psychological preparation, surgical planning, and attention to detail, these male characteri…