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Efficacy and safety of intra-articular botulinum toxin injection therapy for joint pain: A systematic review and meta-analysis.
[BACKGROUND] Studies conducted in various animal models of joint pain showed an anti-nociceptive effect of intra-articular botulinum toxin type A (BoNT-A). Randomized controlled trials (RCTs) in humans suggest a potential effect but results…
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Ultrasound-guided intra-muscular botulinum toxin A in athletes with chronic adductor-related groin-pain: A retrospective observational study.
[INTRODUCTION] Chronic adductor-related groin pain (AP) is a frequent and disabling sport condition. Intra-muscular injection of botulinum toxin A may have positive effects on pain in some chronic tendinitis. We aimed to describe the short-…
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Intra-articular botulinum toxin A injection for painful base-of-thumb osteoarthritis: a double-blind, randomised, controlled, phase 3 trial (RHIBOT).
[BACKGROUND] Intra-articular botulinum toxin A injection might have analgesic effects in patients with joint diseases. We aimed to compare the effects of intra-articular botulinum toxin A injection with those of intra-articular saline injec…
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Intra-articular botulinum toxin A for base-of-thumb osteoarthritis: protocol for a randomised trial (RHIBOT).
[INTRODUCTION] Recent studies have suggested that intra-articular injection of botulinum toxin A (BTA) may have analgesic effects in degenerative joint diseases. We aim to assess the efficacy of intra-articular injection of BTA associated w…
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Evidence and recommendations for use of intra-articular injections for knee osteoarthritis.
Pharmacological treatments are widely recommended in international guidelines for management of osteoarthritis (OA). However, the use of intra-articular (IA) therapies of diverse active drugs remains controversial. We critically reviewed st…