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High-resolution mass spectrometry and enzyme-linked immunosorbent assay for detection of residual botulinum concentrations in a mouse model of botulism.
[BACKGROUND] Botulinum toxin type A is widely used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia. We aim to develop a user-friendly method for detecting cases of medical botulinum tox…
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A neonatal rat model of progressive left ventricular pressure overload induced by abdominal aortic banding microsurgery.
[OBJECTIVE] Left ventricular pressure overload models using adult mice or rats were developed 60 years ago; however, a neonatal mouse model of left ventricular pressure overload was reported only 5 years ago. Moreover, how left ventricular …
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Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage.
[BACKGROUND] Increased pulmonary blood flow (IncPBF), one of the most important features of many children with congenital heart diseases, is well-known as a prerequisite for the induction of pulmonary arterial hypertension. However, due to …
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Machine learning approach to predict surgical site infection in head and neck squamous cell carcinoma patients after free flap reconstruction.
Head and neck squamous cell carcinoma (HNSCC) patients undergoing free flap reconstruction face a high risk of surgical site infection (SSI). Logistic regression (LR) models for SSI prediction are limited by linear assumptions, while machin…
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VYC-25L Is Safe and Effective for Enhancing the Chin and Jawline by Correcting Chin Retrusion in Chinese Adults.
[BACKGROUND] Individuals with chin retrusion may seek chin and lower jawline aesthetic enhancement. [OBJECTIVES] To evaluate VYC-25L (Juvéderm Volux XC; Allergan Aesthetics, an AbbVie company), a lidocaine-containing injectable hyaluronic …
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Safety and Efficacy of a New Hyaluronic Acid Filler for Lip Augmentation: A Prospective, Multicenter, Randomized, Controlled Study.
[BACKGROUND] Lip augmentation has become increasingly accepted and popular. However, there are still a few approved lip fillers that are versatile, biocompatible, suitable for lip enhancement, and backed by large-scale clinical trials. [OB…
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Leveraging AAV1-Rac1T17N to prevent experimental proliferative vitreoretinopathy.
[BACKGROUND] Platelet-derived growth factor receptor β (PDGFRβ) is the principal PDGFR isoform in retinal pigment epithelial (RPE) cells from the epiretinal membranes of patients with proliferative vitreoretinopathy (PVR). Ras-related C3 Bo…
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Guiding Needle-Assisted Redistribution of Orbital Fat in Transconjunctival Lower Eyelid Blepharoplasty.
[BACKGROUND] Accurate fat redistribution after lacrimal trough ligament release by the conjunctival approach is difficult due to the limited surgical field of view. Therefore, creative methods are urgently needed. [AIMS] To explore an inno…
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[Clinical application of endoscopic radical mastectomy for breast cancer combined with total pectoral muscle reconstruction with breast implants].
[OBJECTIVE] To investigate the effectiveness of endoscopic radical mastectomy for breast cancer combined with total pectoral muscle reconstruction with breast implants. [METHODS] The clinical data of 138 female patients with breast cancer …
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Right ventricular volume overload reboots cardiomyocyte proliferation via immune responses.
[BACKGROUND] Right ventricular volume overload (RVVO) is one of the most important hemodynamic characteristics in children with congenital heart disease (CHD) and heart failure, and cardiomyocyte (CM) proliferation is one of the most vital …
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A bibliometric analysis of cerebral palsy from 2003 to 2022.
[PURPOSE] This bibliometric study explores cerebral palsy (CP) research from 2003 to 2022 to reveal the topic hotspots and collaborations. [METHODS] We retrieved studies on CP from the Web of Science Core Collection from 2003 to 2022 and t…
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Analgesia Using Transcutaneous Electric Nerve Stimulation in Office Bladder Chemodenervation, a Randomized Controlled Trial.
[IMPORTANCE] Office bladder chemodenervation, performed via cystoscopy with intradetrusor onabotulinumtoxinA (BOTOX) injections, is a common treatment for overactive bladder/urge urinary incontinence. Transcutaneous electric nerve stimulati…
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Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice.
Sepsis progression is significantly associated with the disruption of gut eubiosis. However, the modulatory mechanisms of gut microbiota operating during sepsis are still unclear. Herein, we investigated how gut commensals impact sepsis dev…
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Application of retaining the vessels around the orbicularis oculi muscle in blepharoplasty.
[OBJECTIVE] To investigate the effect of retaining the vessels around the orbicularis oculi muscle on reducing local swelling after blepharoplasty. [METHODS] A total of 309 patients undergoing blepharoplasty (total incision) were observed …
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Morphological Measurement of Asian Osteal Nasal Base for Paranasal Augmentation.
[BACKGROUND] Paranasal augmentation has been a popular approach in restoring Asian patients' lateral profile. Irregular surface in the surgical area emphasizes the importance of morphological evidence for the preoperative evaluation and the…
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Injectable Cartilage Microtissue Regenerated by Autologous Chondrocytes for Nasal Augmentation: A 5-Year Follow-Up Study.
[BACKGROUND] A lack of ideal filling materials is a critical limitation in current rhinoplasty. Cartilage sheet regeneration by autologous chondrocytes is expected to provide an ideal source of material. However, the inability to perform mi…
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Comprehensive complication index: A new reporting standard for postoperative complications of free-flap reconstruction in head and neck cancer patients.
[OBJECTIVE] We aimed to validate and evaluate the comprehensive complication index (CCI) as a measure of postoperative complications (POCs) in the patients with head and neck squamous cell carcinoma (HNSCC) who had undergone free-flap recon…
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Evaluating Sensation Recovery in Noninnervated Free Flaps Used for Oral Reconstruction.
[PURPOSE] Association between time and sensation recovery in noninnervated flaps remains unclear. Our goal was to evaluate the recovery of sensation in noninnervated free flaps used for oral reconstruction. [MATERIALS AND METHODS] A prospe…
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Chelate-functionalized magnetic micelles for sequestration of cisplatin.
Many cancer patients suffer permanent hearing loss due to accumulation of ototoxic cisplatin in the inner ear. In this study, two types of 100 nm magnetic micelles were developed to sequester cisplatin from aqueous solutions, with the goal …
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Soft and stretchable organic bioelectronics for continuous intraoperative neurophysiological monitoring during microsurgery.
In microneurosurgery, it is crucial to maintain the structural and functional integrity of the nerve through continuous intraoperative identification of neural anatomy. To this end, here we report the development of a translatable system le…
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Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension.
[OBJECTIVE] Mutations in (bone morphogenetic protein receptor 2) are associated with familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular link between loss of BMPR2 in pulmonary artery smooth muscle cel…
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Use of LetibotulinumtoxinA for Aesthetic Treatment of Asians: A Consensus.
Treatment of wrinkles and dynamic lines with botulinum toxin has been a routine practice for years in aesthetic clinical settings. The effective treatment of wrinkles requires a comprehensive understanding of facial expression muscles and t…
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Preventing Retraction With Use of Primary Eyelid Spacer Grafts in Cosmetic Lower Lid Blepharoplasty.
[BACKGROUND] Lower eyelid retraction is a challenging complication that can develop after a cosmetic lower eyelid blepharoplasty. Factors such as proptosis and negative orbital vector may place patients at a higher risk for developing postb…
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Autologous Shuffling Lipo-Aspirated Fat Combined Mechanical Stretch in Revision Rhinoplasty for Severe Contractures in Asian Patients.
[BACKGROUND] A severely contracted nose is a common occurrence. Intraoperative expansion is not sufficient to soften the severely constricted nasal envelope, which poses challenges in revision rhinoplasty. In recent years, adjuvant therapie…
- Correction to: Autologous Shuffling Lipo-Aspirated Fat Combined Mechanical Stretch in Revision Rhinoplasty for Severe Contractures in Asian Patients.
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Rhinoplasty with Simultaneous Autologous Full-Face Fat Transfer for Asian Facial Contouring Balance: A Retrospective Study.
[BACKGROUND] The aesthetic facial contouring procedures have gained an increasing popularity in the Asian population. Nevertheless, currently, there are few specific literature assessments and studies on the outcomes of rhinoplasty combined…
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Classification of Alar Dynamic Aesthetic in an Asian Female Population: Experts or Automatic Algorithms?
[AIM] To provide referenced classifications of alar dynamic aesthetics from both subjective and objective perspectives for determining proper surgical strategies in alarplasty. [METHODS] A total of 150 healthy Asian female participants wer…
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Application of Paranasal Augmentation Rhinoplasty in Asians With Midfacial Concavity.
[BACKGROUND] For Asian rhinoplasty patients with midfacial concavity, the conventional method is to solve the problem by using structural rhinoplasty to increase the nasal height and length. However, the results are not satisfying, and many…
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The Morphological and Functional Effects of the Endoscope-Assisted One-Stage Approach for Crooked Nose.
[BACKGROUND] A crooked nose is an external nose deformity predominantly caused by congenital aplasia or acquired secondary to trauma or surgery, often accompanied by a deviated nasal septum. Patients with crooked nose have dual needs to imp…
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Postoperative Complications of Free Flap Reconstruction in Moderate-Advanced Head and Neck Squamous Cell Carcinoma: A Prospective Cohort Study Based on Real-World Data.
[BACKGROUND] Postoperative complications (POCs) of moderate-advanced head and neck squamous cell carcinoma (HNSCC) after free flap reconstruction have received little attention. We investigated the risk factors that lead to POCs and their i…