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Detection of a streptogramin A O-acetyltransferase gene () in the chromosome of isolated from infants in the United States.
Infant botulism, the most common form of botulism in the United States, occurs when botulinum toxin-producing clostridia colonize the infant's gut and produce botulinum neurotoxin (BoNT). This condition is treated with botulinum antitoxin a…
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Draft Genome Sequence of Clostridium botulinum Subtype /A5(B2').
Here, we report the draft genome sequence of Clostridium botulinum strain CDC76130, which harbors a rare botulinum toxin gene () complex arrangement of /A5 and truncated /B2 within the same toxin gene cluster.…
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Genomic Characterization of Strains From a Cluster of Infant Botulism Type A in a Small Town in Colorado, United States.
Three cases of infant botulism were reported in a small Colorado town between 1981 and 1984. The first two cases occurred in 1981, 6 months apart, and the third case occurred in 1984. type A was isolated from stool of all three case patien…
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Type B Isolated From a Wound Botulism Case Due to Injection Drug Use Resembles Other Local Strains Originating From Hawaii.
produces botulinum neurotoxin (BoNT), which can lead to death if untreated. In the United States, over 90% of wound botulism cases are associated with injection drug use of black tar heroin. We sought to determine the phylogenetic relatedne…
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Draft Genome Sequences for Dual-Toxin-Producing Clostridium botulinum Strains.
Here, we present draft genome sequences for three Clostridium botulinum strains that produce multiple botulinum toxin serotypes. Strains that produce two toxins are rare; however, one of these strains produces subtype B5 and F2 toxins, and …
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Molecular Characterization of Harboring the /B7 Gene.
produces botulinum neurotoxin (BoNT), which is the causative agent of botulism, a rare but serious disease that can result in death if not treated. Infant botulism occurs when colonizes the intestinal tract of infants and produces BoNT. It…
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Finished Whole-Genome Sequences of Toxin Subtype E4 and Toxin Subtype F7 Strains.
and species have been known to produce botulinum toxin types E and F, respectively, which can cause botulism, a rare but serious neuroparalytic disease. Here, we present finished genome sequences for two of these clinically relevant strain…
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Type F Infant Botulism: Investigation of Recent Clusters and Overview of This Exceedingly Rare Disease.
From 1976 to 2016, neurotoxigenic Clostridium baratii type F caused 18 (…
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A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A Antitoxin.
Botulism is a potentially fatal paralytic disease caused by the action of botulinum neurotoxin (BoNT) on nerve cells. There are 7 known serotypes (A-G) of BoNT and up to 40 genetic variants. Clostridium botulinum strain IBCA10-7060 was rece…
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Characterizing the fecal microbiota of infants with botulism.
[BACKGROUND] Infant botulism is the most prevalent form of botulism in the USA, representing 68.5 % of cases reported from 2001-2012. Infant botulism results when botulinum toxin-producing clostridia (BTPC) colonize the infant gut with conc…