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Microvascular Free-Flap Head and Neck Reconstruction: The Utility of the Modified Frailty Five-Item Index.
[BACKGROUND] Microvascular free tissue transfer is a common tool for the reconstruction of oncologic head and neck defects. Adequate preoperative assessment can aid in appropriate risk stratification and peri-operative optimization. The mo…
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Management of the Acute Loss of a Free Flap to the Head and Neck-A Multi-institutional Review.
[OBJECTIVES/HYPOTHESIS] To review the management of failed free tissue transfers among four large institutions over a 13-year period to provide data and analysis for a logical, algorithmic, experience-based approach to the management of fai…
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Neuropeptide Y nerve paracrine regulation of prostate cancer oncogenesis and therapy resistance.
[BACKGROUND] Nerves are key factors in prostate cancer (PCa) progression. Here, we propose that neuropeptide Y (NPY) nerves are key regulators of cancer-nerve interaction. [METHODS] We used in vitro models for NPY inhibition studies and su…
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Influence of the neural microenvironment on prostate cancer.
[BACKGROUND] Nerves are key factors in prostate cancer (PCa), but the functional role of innervation in prostate cancer is poorly understood. PCa induced neurogenesis and perineural invasion (PNI), are associated with aggressive disease. […