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Comparison of Pharmacokinetics of Long-Acting Local Analgesics: CPL-01, a Novel Extended-Release Ropivacaine, Demonstrates Consistent and Predictable Exposure Compared with Liposomal Bupivacaine.
[BACKGROUND AND OBJECTIVE] There is a significant medical need for improved long-acting local anesthetics to decrease postsurgical pain and reduce postoperative opioid use. While ropivacaine is considered a safer local anesthetic than bupiv…
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The safety of liposome bupivacaine, a novel local analgesic formulation.
[OBJECTIVE] Pooled safety data from 10 randomized, double-blind studies of liposome bupivacaine, a novel local analgesic formulation, were examined. [METHODS] Eight hundred twenty-three patients received liposome bupivacaine (dose, 66 to 5…
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Impact of local administration of liposome bupivacaine for postsurgical analgesia on wound healing: a review of data from ten prospective, controlled clinical studies.
[BACKGROUND] Liposome bupivacaine is a liposomal formulation that allows delivery of bupivacaine for 96 hours with a single local administration. It is indicated for the management of postsurgical pain. [OBJECTIVE] This retrospective revie…
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The efficacy and safety of DepoFoam bupivacaine in patients undergoing bilateral, cosmetic, submuscular augmentation mammaplasty: a randomized, double-blind, active-control study.
[BACKGROUND] Breast augmentation can result in significant postsurgical pain. [OBJECTIVES] The authors evaluate the extent and duration of analgesia achieved with extended-release DepoFoam bupivacaine (Pacira Pharmaceuticals, Inc., Parsipp…
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A two-year observational study assessing the safety of DepoFoam bupivacaine after augmentation mammaplasty.
[BACKGROUND] Two-year safety outcomes in patients who received DepoFoam bupivacaine during two prior breast augmentation studies were evaluated. [OBJECTIVES] The authors assess the clinical sequelae observed during follow-up examination wi…