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2건 · 최신순-
Dysregulation of microRNA expression drives aberrant DNA hypermethylation in basal-like breast cancer.
Basal-like breast cancers frequently express aberrant DNA hypermethylation associated with concurrent silencing of specific genes secondary to DNMT3b overexpression and DNMT hyperactivity. DNMT3b is known to be post-transcriptionally regula…
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Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor.
[INTRODUCTION] Tumor-initiating cells (TIC) are being extensively studied for their role in tumor etiology, maintenance and resistance to treatment. The isolation of TICs has been limited by the scarcity of this population in the tissue of …