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Isolation and characterization of a breast progenitor epithelial cell line with robust DNA damage responses.
We report the establishment of a breast epithelial cell model that undergoes growth arrest at different stages of the cell cycle depending upon the DNA damaging agents encountered. Primary breast epithelial cells from normal reductive mammo…
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Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression.
Although growth factors and extracellular matrix (ECM) are recognized as important contributors to breast epithelial growth, morphogenesis, hormone responsiveness, and neoplastic progression, the influence of functional interactions between…
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Regulated CYP19 aromatase transcription in breast stromal fibroblasts.
Extraglandular estrogen synthesis mediates the proliferation of estrogen-responsive breast cancer in postmenopausal women. Aromatase, the cytochrome P450 Cyp19 enzyme, catalyzes the rate-limiting step in estrogen biosynthesis. Activity is p…
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Clomiphene in the treatment of adolescent gynecomastia. Clinical and endocrine studies.
Twelve boys, aged 12 to 19 years, with persistent gynecomastia were treated with the antiestrogen, clomiphene citrate, at a dose of 50 mg/day by mouth for one to three months. The mean breast size decreased by 0% to 36%, with only five boys…