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Ischemia-Reperfusion Injury in Free Flaps: Molecular Mechanisms and Protective Effects of Remote Ischemic Preconditioning.
Ischemia-reperfusion injury remains a major challenge in free flap surgery, contributing to oxidative stress, inflammation, and cell death that impair tissue viability and outcomes. Remote ischemic preconditioning (RIPC) has emerged as a po…
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Systemic downregulation of EV-associated MiRNAs following remote ischemic preconditioning.
Remote ischemic preconditioning (RIPC) is a non-invasive strategy to protect tissues from ischemia-reperfusion injury (IRI), yet its systemic molecular mediators remain incompletely understood. Extracellular vesicles (EVs), particularly the…
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Autologous Reconstruction After Failed Implant-Based Breast Reconstruction: A Comparative Multifactorial Outcome Analysis.
[INTRODUCTION] Failure of an implant-based breast reconstruction often requires a change to an autologous procedure (salvage autologous breast reconstruction [Salv-ABR]). The aim of this study was to compare surgical and patient-reported ou…
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Free-flap reconstruction of the lower limb in octogenarians - A comparative analysis of indications, management, and outcomes.
[INTRODUCTION] Impaired microcirculation, along with an increase in chronic medical conditions in the geriatric cohort, may favor the development of soft-tissue defects in the lower extremity and equally impair the options for plastic-recon…
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Postoperative Remote Ischemic Conditioning (RIC) significantly improves entire flap microcirculation beyond 4 hours.
[OBJECTIVE] Free flap transfer is a safe and reliable technique for soft tissue reconstruction. However, impaired flap perfusion with consecutive microcirculatory failure leading to partial or total flap failure remains a clinically relevan…
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[Analysis of Efficency, Cost Structure and Revenues of ALT Free Flaps in Extremity Reconstruction].
Microvascular reconstructions can be lengthy procedures lasting the entire day. As a result of unforeseeable events, the standardization of these procedures can be challenging. Moreover, the length of these procedures varies strongly, which…
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Improvement of Superficial and Deep Cutaneous Microcirculation Due to Axillary Plexus Anesthesia Impaired by Smoking.
[BACKGROUND] Understanding microvascular physiology is key to any reconstructive procedure. Current concepts in anesthesia increasingly involve regional peripheral nerve blockade during microvascular reconstructive procedures. Whereas favor…
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[Soft tissue sarcomas: limb salvage using reconstructive plastic surgery techniques].
The treatment of choice for soft tissue sarcomas with local involvement is still the complete surgical removal into healthy tissue. The aim of surgery is to achieve tumor-free resection margins in the sense of a R0 resection. No other treat…