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The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes.
HACE1 is a HECT family E3 ubiquitin-protein ligase with broad but incompletely understood tumor suppressor activity. Here, we report a previously unrecognized link between HACE1 and signaling complexes containing mammalian target of rapamyc…
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HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner.
Uncovering the mechanisms that underpin how tumor cells adapt to microenvironmental stress is essential to better understand cancer progression. The HACE1 (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase) gene is a tum…