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5건 · 최신순-
The role of loading in murine models of rotator cuff disease.
Rotator cuff disease pathogenesis is associated with intrinsic (e.g., age, joint laxity, muscle weakness) and extrinsic (e.g., mechanical load, fatigue) factors that lead to chronic degeneration of the cuff tissues. However, etiological stu…
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Transient neonatal shoulder paralysis causes early osteoarthritis in a mouse model.
Neonatal brachial plexus palsy (NBPP) occurs in approximately 1.5 of every 1,000 live births. The majority of children with NBPP recover function of the shoulder. However, the long-term risk of osteoarthritis (OA) in this population is unkn…
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The multiscale structural and mechanical effects of mouse supraspinatus muscle unloading on the mature enthesis.
The musculoskeletal system is sensitive to its loading environment; this is of particular concern under conditions such as disuse, paralysis, and extended-duration space flight. Although structural and mechanical changes to tendon and bone …
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Scleraxis is required for the development of a functional tendon enthesis.
The attachment of dissimilar materials is a major engineering challenge, yet this challenge is seemingly overcome in biology. This study aimed to determine how the transcription factor Scleraxis (Scx) influences the development and maturati…
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Chronic Degeneration Leads to Poor Healing of Repaired Massive Rotator Cuff Tears in Rats.
[BACKGROUND] Chronic rotator cuff tears present a clinical challenge, often with poor outcomes after surgical repair. Degenerative changes to the muscle, tendon, and bone are thought to hinder healing after surgical repair; additionally, th…