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Hypertrophic scar formation is associated with an increased number of epidermal Langerhans cells.
The exact pathogenesis of hypertrophic scar and keloid formation is still unknown and a good therapy to prevent or treat these scars is lacking. Because immunological processes seem to be important in excessive scar formation, immunological…
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Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars.
In predisposed individuals, wound healing can lead to hypertrophic scar or keloid formation, characterized by an overabundant extracellular matrix. It has recently been shown that hypertrophic scars are accompanied by abnormal keratinocyte …