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49건 · 최신순-
Rac1 promotes exosome secretion from proximal renal tubules to accelerate DKD.
Chronic low-grade sterile inflammation is one hallmark of diabetic kidney disease (DKD). Exosomes secretion from renal cells plays an important role in the transmission of inflammatory substances, which is associated with DKD. Ras-related C…
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Impact of intravenous tranexamic acid administration on reduction mammoplasty outcomes.
[BACKGROUND] The growing use of tranexamic acid (TXA) in plastic surgery warrants an accurate analysis of efficacy for body contouring indications. We offer the largest cohort evaluation of intravenous TXA use in minimizing postoperative co…
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Non-inverted and single-layer "plastic bag" ILM flap novel technique to treat large macular holes.
[PURPOSE] To assess the efficacy and safety of a novel non-inverted, free single-layer internal limiting membrane (ILM) flap technique for treating large full-thickness macular holes (FTMHs). [METHODS] Patients with FTMHs underwent a stand…
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One-stage hybrid operation for hypervascular central nervous system tumors: a single-center experience of 31 cases.
[BACKGROUND] Surgical resection for hypervascular central nervous system tumors poses a significant challenge for neurosurgeons. Controversy remains about the effect and safety of the traditional therapeutic mode, which combines preoperativ…
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The Efficacy of Half Purse Suture Technique in Eliminating "Dog-Ear" Deformity at Donor Site Incision in Deep Inferior Epigastric Perforator Flap (DIEP) Breast Reconstruction.
BackgroundTo evaluate the effectiveness of the half purse suture technique in eliminating the "dog-ear" deformity at the donor site incision of the Deep Inferior Epigastric Perforator flap (DIEP) for breast reconstruction.MethodFrom May to …
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TNFAIP8L2 maintains hair cell function and regulates age-related hearing loss via mTORC1 signaling.
Age-related hearing loss (ARHL) is one of the most prevalent and complex disorders. Our previous study demonstrated that abnormal activation of mammalian target of rapamycin complex 1 (mTORC1) signaling in the cochlear neurosensory epitheli…
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A comparative study on the short-term and long-term efficacy of endoscopic lipolysis, liposuction, and traditional open excision in gynecomastia treatment.
[OBJECTIVE] This study investigates the comparative short-term and long-term efficacy of endoscopic lipolysis and liposuction versus traditional open excision in the treatment of gynecomastia. [METHODS] A total of 140 male patients diagnos…
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Predictors of Difficult Laryngeal Exposure in Suspension Laryngoscopy: A Systematic Review and Meta-Analysis.
[OBJECTIVES] Considerable research has been focused on independent predictors of difficult laryngeal exposure (DLE) during suspension laryngoscopy. However, previous studies have yielded inconsistent results and conclusions. Consequently, w…
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Reconstruction of Extensive Maxillary Defects Using Flow-Through Fibula Free Flap With Anterolateral Thigh Free Flap.
[BACKGROUND] The maxillary defects left unreconstructed or inadequately reconstructed often result in significant functional and esthetic impairments. Adequate reconstruction of extensive maxillary defects requires a sufficient volume of ha…
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Division of neuromuscular compartments and localization of the center of the intramuscular nerve-dense region in pelvic wall muscles based on Sihler's staining.
The innervation of the pelvic wall muscles is not very clear. This study aimed to reveal the division of neuromuscular compartments and localize the surface position and depth of the center of the intramuscular nerve-dense region (CINDR) of…
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Localisation of the centre of the highest region of muscle spindle abundance of anterior forearm muscles.
The centre of the highest region of muscle spindle abundance (CHRMSA) in the intramuscular nerve-dense region has been suggested as the optimal target location for injecting botulinum toxin A to block muscle spasms. The anterior forearm mus…
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Division of neuromuscular compartments and localization of the center of the highest region of muscle spindles abundance in deep cervical muscles based on Sihler's staining.
[PURPOSE] The overall distribution pattern of intramuscular nerves and the regions with the highest spindle abundance in deep cervical muscles have not been revealed. This study aimed to reveal neuromuscular compartmentalization and localiz…
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Is antibiotic prophylaxis generally safe and effective in surgical and nonsurgical scenarios? Evidence from an umbrella review of randomized controlled trials.
[BACKGROUND] The authors aimed to comprehensively evaluate the efficacy and safety of antibiotic prophylaxis through surgical and nonsurgical scenarios and assess the strength of evidence. [MATERIALS AND METHODS] The authors performed an u…
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ADM-assisted prepectoral breast reconstruction is not associated with high complication rate as before: a Meta-analysis.
Implant-related breast reconstruction can be divided into subpectoral breast reconstruction (SPBR) and prepectoral breast reconstruction (PPBR) according to the different anatomical planes. The previous stereotype was that PPBR had a high c…
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Horizontal middle partial laryngectomy with cricothyroidopexy: an effective treatment for stage T1b glottic carcinoma.
[BACKGROUND] The current treatment options for T1b glottic carcinoma often lead to poor treatment outcomes or voice quality. [OBJECTIVES] This study evaluates the therapeutic efficacy of horizontal middle partial laryngectomy with cricothy…
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Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.
[OBJECTIVE] Diabetic kidney disease (DKD) is characterized by the abnormal deposition of oxidized low-density lipoprotein (ox-LDL), which contributes to podocyte damage. Klotho, an aging suppressor that plays a critical role in protecting p…
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Microscopic Transsphenoidal Resection of Giant Pituitary Adenomas: Analysis of the Factors Limiting the Degree of Resection in 73 Cases.
[PURPOSE] To analyze the risk factors affecting the gross-total resection of giant pituitary adenomas using a transsphenoidal approach under a microscope to provide a reference basis for formulating an appropriate surgical strategy. [METHO…
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How to Precisely Open the Internal Auditory Canal for Resection of Vestibular Schwannoma the Retrosigmoid Approach.
[OBJECTIVE] The aim of this study was to investigate how to precisely expose the intrameatal portion of vestibular schwannomas (VSs) without damaging the labyrinth. [METHODS] This was a retrospective study of patients who had undergone ret…
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Multimodal treatments of brain arteriovenous malformations: a comparison of microsurgical timings after endovascular embolization.
[BACKGROUND] To compare the clinical outcomes of hybrid microsurgery and embolization with multi-staged procedure for patients harboring brain arteriovenous malformations (bAVMs). [METHODS] We retrospectively reviewed bAVM patients from a …
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Inclusion of a latissimus dorsi segment in an extended lower trapezius musculocutaneous flap facilitates complex defect reconstruction.
The pedicled lower trapezius musculocutaneous flap (LTMF) can extend far beyond the lateral border of the trapezius muscle, with a reliable blood supply. However, the distal part of the extended LTMF lacks a muscular component, limiting its…
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Infusion management associated with prolonged length of stay following free flap reconstruction of head and neck defects: A propensity score matching study.
[BACKGROUND] Surgical resection of the primary lesion and reconstruction of the defects with free flaps are common treatments for head and neck cancer (HNC). However, various variables can lead to prolonged length of stay (LOS). The aim of …
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Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.
[OBJECTIVE] Inflammation is central to the development and progression of diabetic nephropathy (DN). Although the exact mechanisms of inflammation in the kidney have not been well elucidated, pyrin domain containing 3 (NLRP3) inflammasome a…
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Localization of the Center of the Intramuscular Nerve Dense Region of the Suboccipital Muscles: An Anatomical Study.
[PURPOSE] This study aimed to determine the body surface puncture position and depth of the center of the intramuscular nerve dense region in the suboccipital muscle to provide morphological guidance for accurate botulinum toxin A injection…
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Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline.
[BACKGROUND] The proliferation ability and autophagy level of pulmonary artery endothelial cells (PAECs) play an important role in promoting the development of pulmonary artery hypertension (PAH), and there is still no effective treatment f…
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Localization of the nerves innervating the pelvic floor muscles: An application to pelvic pain treatment.
The aim of this study was to achieve accurate localization of the body surface position and depth of the center of the intramuscular nerve dense region (CINDR) of the pelvic floor muscles and to establish a target site for treating pelvic f…
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Ultrasound-guided injection of botulinum toxin type A blocks cardiac sympathetic ganglion to improve cardiac remodeling in a large animal model of chronic myocardial infarction.
[BACKGROUND] Strategies to improve various cardiovascular diseases by blocking cardiac sympathetic ganglion have been increasingly available currently. Botulinum toxin type A (BTA), a typical neurotoxin, has been shown to block neural trans…
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Mandibular stability and condylar changes following orthognathic surgery in mandibular hypoplasia patients associated with preoperative condylar resorption.
[OBJECTIVES] To evaluate postoperative mandibular stability and condylar changes in patients with mandibular hypoplasia and preoperative condylar resorption (CR) undergoing orthognathic surgery. [MATERIALS AND METHODS] Fifty-four patients …
- Assessing effects of preoperative nerve block on pain and opioid use after breast reduction: Methodological issues.
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"An integrated clip-shaped costal cartilage carving approach for rhinoplasty".
[BACKGROUND] Nasal tip management is considered to be one of the most complicated and challenging parts of rhinoplasty in East Asian patients. Within current rhinoplasty surgical practice, costal cartilage serves as an ideal source for graf…
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Active and Adequate Exposure of the Facial Nerve and Chorda Tympani Nerve to Improve the Safety of Cochlear Implantation.
[BACKGROUND] The posterior tympanum approach of cochlear implantation is easy to damage the facial nerve and cord tympanic nerve. Therefore, we need to improve the safety of cochlear implantation. [OBJECTIVES] To discuss the safety and fea…