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19건 · 최신순-
Endoscopic Topical Application (ETA) Therapy for Refractory Overactive Bladder: A First-in-Human Report.
Refractory overactive bladder (OAB) remains a clinical challenge despite established therapies, such as anticholinergics, β3-agonists, and intradetrusor botulinum toxin (BTX). Emerging evidence suggests that sensory mechanisms within the bl…
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Short-term Efficacy of Botulinum Toxin A for Refractory Overactive Bladder in Female Patients.
[BACKGROUND/AIM] This study aimed to assess the effectiveness and safety of 100 U onabotulinumtoxinA (also known as botulinum toxin type A) for overactive bladder (OAB) and urgency urinary incontinence (UUI) in Japanese women. [PATIENTS AN…
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Bladder Trigone as a Sensory Hub: A Narrative Review.
The bladder trigone is an anatomically and functionally distinct region within the lower urinary tract (LUT), characterized by a dense network of afferent sensory fibers, specialized urothelial interactions, and prominent mechanotransductio…
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Twin Tower-shaped Anastomosis: Two Comitant Veins Anastomosed to a Single Recipient Vein in an End-to-end Fashion.
In some cases of free flap transfer, two comitant veins must be anastomosed to a single suitable recipient vein to avoid congestion due to the lack of network between the two comitant veins. In this situation, both veins are mostly anastomo…
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Combined Exoscopic and Endoscopic Two-Step Keyhole Approach for Intracranial Meningiomas.
The advantages of neuroendoscopic surgery are the wide viewing angle and the freedom of an axis of view with minimal surgical trauma. With the advent of the exoscope, which has similar advantages to endoscopy, such as a small body and ergon…
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Immediate one-stage breast reconstruction for an 85-year-old breast cancer patient using deep inferior epigastric perforator flap surgery.
The deep inferior epigastric perforator (DIEP) flap is widely recognized as safe for use as a first-choice option in autologous tissue breast reconstruction; however, DIEP is often not performed for breast reconstruction in the elderly. We …
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Combined Exoscopic and Endoscopic Technique for Craniofacial Resection.
We determined the feasibility of the combined exoscopic-endoscopic technique (CEE) as an alternative to the microscope in craniofacial resection (CFR). This retrospective study was conducted at a single institution and included eight consec…
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Atomic force microscopic image data of botulinum neurotoxin complexes with different molecular sizes.
This data article provides atomic force microscopy (AFM) amplitude images of botulinum toxin complex (TC) molecules produced by serotype D strain. produces different-sized TC molecules, such as a complex of botulinum neurotoxin and nontox…
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Construction of "Toxin Complex" in a Mutant Serotype C Strain of Clostridium botulinum Harboring a Defective Neurotoxin Gene.
A non-toxigenic mutant of the toxigenic serotype C Clostridium botulinum strain Stockholm (C-St), C-N71, does not produce the botulinum neurotoxin (BoNT). However, the original strain C-St produces botulinum toxin complex, in which BoNT is …
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Building-block architecture of botulinum toxin complex: Conformational changes provide insights into the hemagglutination ability of the complex.
produces the botulinum neurotoxin (BoNT). Previously, we provided evidence for the "building-block" model of botulinum toxin complex (TC). In this model, a single BoNT is associated with a single nontoxic nonhemagglutinin (NTNHA), yielding …
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Reversible Association of the Hemagglutinin Subcomplex, HA-33/HA-17 Trimer, with the Botulinum Toxin Complex.
Botulinum neurotoxin (BoNT) associates with nontoxic proteins, either a nontoxic nonhemagglutinin (NTNHA) or the complex of NTNHA and hemagglutinin (HA), to form M- or L-toxin complexes (TCs). Single BoNT and NTNHA molecules are associated …
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Conformational divergence in the HA-33/HA-17 trimer of serotype C and D botulinum toxin complex.
Clostridium botulinum produces a large toxin complex (L-TC) comprising botulinum neurotoxin associated with auxiliary nontoxic proteins. A complex of 33- and 17-kDa hemagglutinins (an HA-33/HA-17 trimer) enhances L-TC transport across the i…
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"Non-Toxic" Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity.
The botulinum neurotoxin (BoNT) causes muscle paralysis and is the most potent toxin in nature. BoNT is associated with a complex of auxiliary "Non-Toxic" proteins, which constitute a large-sized toxin complex (L-TC). However, here we repor…
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Data describing inhibitory profiles of sugars against hemagglutination by the botulinum toxin complex of serotypes C and D.
Serotype C and D of produce botulinum toxin complex (TC), which is comprised of botulinum neurotoxin, nontoxic nonhemagglutinin, and hemagglutinins (HAs). The TC is capable of aggregating equine erythrocytes via interaction between one of …
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Hemagglutinin gene shuffling among Clostridium botulinum serotypes C and D yields distinct sugar recognition of the botulinum toxin complex.
Clostridium botulinum strains produce a large-sized toxin complex (TC) that is composed of botulinum neurotoxin (BoNT), non-toxic non-hemagglutinin and three different hemagglutinins (HA-70, HA-33 and HA-17). HA components enhance toxin del…
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Augmentation with cartilage grafts around the pyriform aperture to improve the midface and profile in binder's syndrome.
The two major surgical methods for improving the midface and its profile of Binder's syndrome (commonly referred to as "dish face" deformity of "C-shape" deformity) are bone or cartilage graft and osteotomy. The bone or cartilage graft limi…
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Vermilionplasty using medical tattooing after radial forearm flap reconstruction of the lower lip.
Vermilionplasty using medical tattooing was performed after radial forearm flap reconstruction of the lower lip in 2 patients. This technique is easy to perform in the outpatient setting, does not involve sacrifice of tissue, and results in…
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Semiquantitative correction of posttraumatic enophthalmos with sliced cartilage grafts.
A simple surgical technique for correcting posttraumatic enophthalmos is described. The steps are as follows: (1) a plaster mold is obtained of the patient's face, (2) wax is added to the enophthalmic eye of the plaster mold until it become…
- [Cystoplasty of the sigmoid for atrophic bladder due to tuberculosis, with special reference to its follow-up study].