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96건 · 최신순-
Innovative Non-Inverted ILM Free Flap Covering Technique for Unclosed Macular Hole Repair.
[OBJECTIVE] To examine the safety and effectiveness of non-inverted ILM Free Flap combined with the SPOT technique (Sub-Perfluorocarbon liquid (PFCL) injection of Ocular viscoelastic device (OVD) Technique) in the treatment of unclosed macu…
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Preoperative Professional Tooth Cleaning as a Preventive Measure for Postoperative Pneumonia in OSCC Patients: A Retrospective Study.
[BACKGROUND] Professional tooth cleaning is a simple, low-cost preoperative oral intervention. Its role in reducing postoperative complications in oral squamous cell carcinoma (OSCC) remains unclear. [METHODS] This retrospective cohort stu…
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Timing of Thickened Liquid Intake After Tongue and Floor-of-Mouth Tumour Reconstruction: A Randomised Controlled Trial.
[OBJECTIVE] This study aimed to determine the optimal timing and viscosity of thickened liquid intake for patients undergoing tongue and floor-of-mouth tumour resection with reconstruction, using VFSS to reduce nasogastric tube dependence, …
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Allogeneic Whole Eye Transplantation in Macaques Achieves 19-Day Graft Survival With Structural and Functional Viability.
[PURPOSE] Whole eye transplantation (WET) is a promising approach for vision restoration in severe ocular damage. This study pioneers an allogeneic whole-eye transplantation model in non-human primates, designed to: (1) Establish standardiz…
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Associations between periodontitis and postoperative infectious complications in OSCC patients: a retrospective study.
[BACKGROUND] Periodontitis is a known risk factor for oral squamous cell carcinoma (OSCC), but its impact on postoperative outcomes remains unclear. [METHODS] This retrospective study included 552 OSCC patients who underwent radical surger…
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Construction of Preoperative Diagnostic Model of Periapical Cyst by Multiparameter Magnetic Resonance Imaging: A Pilot Study.
[AIM] Due to the lack of a predictable and noninvasive method for distinguishing different types of apical periodontitis, it is difficult to estimate the actual prognosis of periapical cysts and the effectiveness of nonsurgical treatment fo…
- Systematic review and meta-analysis comparing postoperative and oncological outcomes between local excision plus radiotherapy versus total mesorectal excision for rectal cancer.
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Establishment and Validation of a Standardized Midface Assessment Protocol Using Three-Dimensional Stereophotogrammetry.
[BACKGROUND] Three-dimensional (3D) stereophotogrammetry has become an essential tool in anthropometry for both clinical and aesthetic purposes. However, to our knowledge, no standardized and validated 3D protocol specifically targeting the…
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Resveratrol Suppresses Sepsis-Induced Micro-vascular Hypo-reactivity Through Rac1-MLCK Pathway.
[INTRODUCTION] Vascular hyporeactivity contributes to a high mortality rate in sepsis. Resveratrol (Res) exhibits anti-inflammatory properties and improves vascular reactivity in septic animals. However, the mechanism of action of Res in se…
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Botulinum Toxin Type A in the Treatment of Primary Axillary Hyperhidrosis:A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Efficacy and Safety in Chinese Patients.
[BACKGROUND] The efficacy and safety of botulinum toxin type A (BoNTA) treatment for primary axillary hyperhidrosis (PAH) have not been explored in the Chinese population. [OBJECTIVES] The objective was to evaluate efficacy and safety of 1…
- Advancement genioplasty as a compensatory measure for mandibular setback-induced airway volume reduction in skeletal class III deformities: a 3D analysis of long-term outcomes.
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Predictors of postoperative epileptic seizures after microsurgical treatment in supratentorial single cerebral cavernous malformations: a retrospective study.
[PURPOSE] Seizures are the most common symptom of supratentorial cerebral cavernous malformations (CCMs). This study aimed to investigate the predictors of seizure freedom in patients with single supratentorial CCMs after microsurgical trea…
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Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells.
Endothelial cells play a critical role in the pathophysiology of ischemia-reperfusion injury (IRI). Although previous studies have shown that IRI can activate PANoptosis, the underlying mechanisms remain unclear. Our research investigates h…
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Impact of cervical osteoarthritis on quality of life after free flap reconstruction in head and neck cancer.
[BACKGROUND] Head and neck squamous cell carcinoma (HNSCC) often requires free flap reconstruction, which involves extensive cervical manipulation. Concurrently, cervical osteoarthritis is increasingly prevalent due to modern lifestyle fact…
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Circumferential periareolar incision length as a risk factor for skin necrosis after nipple-sparing mastectomy with deep inferior epigastric perforator flap reconstruction.
[BACKGROUND] Nipple-sparing mastectomy (NSM) with autologous tissue reconstruction offers excellent cosmetic outcomes but can be complicated by skin necrosis. This study aimed to investigate the risk factors for skin necrosis after NSM with…
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Impact of postoperative complications on patient-reported outcomes in deep inferior epigastric perforator flap breast reconstruction.
[OBJECTIVE] This study aims to investigate the factors that influence the occurrence of complications following deep inferior epigastric perforator (DIEP) flap breast reconstruction, and to determine whether these complications have an impa…
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A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers.
An ideal dermal filler should integrate filling, repair, and anti-aging effects, with immediate tissue augmentation, slow degradation, and progressive stimulation of collagen regeneration. However, commonly used hyaluronic acid (HA) hydroge…
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A Comprehensive Ultrasound Investigation of Lower Facial and Neck Structure.
[BACKGROUND] The jawline and neck significantly influence facial aesthetics. Botulinum toxin and filler are highly favored as minimally invasive jawline rejuvenation procedures. However, little evidence exists on the age-related skin and su…
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Combination of Botulinum Toxin A and Hyaluronic Acid Improved Facial Pore Enlargement Caused by Acne.
[BACKGROUND] Acne often leads to enlarged pores on the facial skin, seriously affecting the patient's appearance. Topical and oral medications have poor efficacy in some cases of severe pore enlargement. [OBJECTIVE] This study aimed to exp…
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Exome and transcriptome analysis link calcium channel pathway aberrations to botulinum toxin A resistance in Hailey-Hailey disease.
[BACKGROUND] The effectiveness of botulinum toxin A (BoNTA) in the treatment of Hailey-Hailey disease (HHD) has shown heterogeneity in recent studies. However, there is currently no research investigating the underlying mechanism behind the…
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Research Progress on the Detection Methods of Botulinum Neurotoxin.
Botulinum neurotoxins (BoNTs), produced by the anaerobic spore-forming bacterium Clostridium botulinum, are among the most potent known biological toxins. BoNTs cause lethal botulism via contaminated food, wound infections, or infant intest…
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Calreticulin-driven immunogenic cell death promotes osteoclast differentiation and osteoarthritis progression via the LRP1/Rac1 signaling.
Aberrant osteoclast activation in subchondral bone is a hallmark of osteoarthritis (OA). This study identifies calreticulin (CALR), a key immunogenic cell death (ICD) marker, as a critical regulator of osteoclast differentiation and OA path…
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P21-activated kinase 4: a potent oncogene, molecular mechanisms and opportunities for targeted therapy.
[UNLABELLED] P21-activated kinase 4 (PAK4), recognized as a key effector protein of the Rho family of small G proteins Cell division regulatory protein 42 homologue (Cdc42) and Ras-related C3 botulinum toxin substrate 1 (Rac1), is a serine/…
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Evaluation of a Cell-Based Potency Assay for Detection of the Potency of TrenibotulinumtoxinE (TrenibotE).
(1) Background: As an innovative drug derived from botulinum neurotoxin serotype E, TrenibotulinumtoxinE demonstrates a rapid onset and shorter effect. Due to concerns regarding specificity, test throughput, and animal welfare, a new cell-b…
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Protruding or concealed: Defining ideal cranioauricular angle via a morphometric analysis in Asians.
[INTRODUCTION] The frontal appearance of ears, usually overlooked in facial aesthetics, has gained increasing attention among Asians. However, a consensus on the ideal cranioauricular angle is currently lacking. This study aims to investiga…
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Lying ear deformity: Personalized fabricated synthetic expanded polytetrafluoroethylene retroauricular prosthesis as an alternative for its correction.
[BACKGROUND] The correction of lying ear is a surgical procedure that can enhance facial aesthetics. In Asian culture, prominent ears are often associated with wealth, and ear protrusion surgery is frequently requested to achieve a slimmer …
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Comparative Study of Adipose-Derived Stem Cells from Localized Scleroderma Patients and Healthy Donors in Treating Skin Fibrosis.
[BACKGROUND] Localized scleroderma (LoS) is an autoimmune disease characterized by fibrosis of the skin and atrophy of the subcutaneous fat tissue. Use of adipose-derived mesenchymal stem cells (ASCs) is a promising treatment approach for L…
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Periostin mediates collagen production, ECM remodeling and myofibroblast differentiation in breast prosthesis capsule formation.
Capsular contraction is the most common complication after breast augmentation or reconstruction, and is the main reason underlying patient dissatisfaction and additional subsequent surgeries. Periostin is an extracellular matrix protein an…
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Early swallowing training after free flap surgery in oral cancer: A randomized controlled trial.
[OBJECTIVE] To explore the effect of early swallowing training on postoperative outcomes of patients who had undergone oral cancer surgery plus free flap reconstruction. [SUBJECTS AND METHODS] In this prospective, randomized controlled tri…
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Effects of personalized oral exercises on swallowing function among patients with oral cancer after free flap transplantation: a cluster randomized controlled trial.
Dysphagia is a common complication in patients with oral cancer who have undergone free flap transplantation. The aim of this cluster randomized controlled trial was to evaluate the effect of personalized oral exercises on swallowing functi…