Clinical and Pathological Features of Early-Stage Metaplastic Carcinoma and Associated Patient Outcomes. (2025)

[BACKGROUND] Metaplastic breast carcinoma (MpBC) is an aggressive subtype of breast cancer that is usually resistant to chemotherapy. Few studies have analyzed the role of immunotherapy and other treatments in early stage MpBC. We identified clinicopathological and sociodemographic factors associated with treatment response and recurrence of disease among patients with nonmetastatic MpBC within 2 hospital systems.

[METHODS] A retrospective study was performed to evaluate female patients diagnosed with Stage I to Stage III MpBC within a safety-net hospital and private cancer center from January 2013 to October 2024.

[RESULTS] We identified 54 patients with MpBC with a mean age of diagnosis of 55.2 years. There were 14 (25.95%) White, 26 (48.1%) Black, and 10 (18.5%) Hispanic patients. Thi