The Molecular Anatomy of Mouse Skin during Hair Growth and Rest.
💡 한 문장 핵심
모발 성장기와 휴지기 동안 마우스 피부의 분자 해부학.
5/5 보강
TL;DR
This work uses single-cell RNA sequencing and single-molecule RNA FISH to provide a systematic molecular atlas of full-thickness skin, determining gene expression profiles and spatial locations that define 56 cell types and states during hair growth and rest.
📑 코퍼스 인용 관계
· 인용됨 59
📑 인용한 논문 (6) ▾
- Rete ridges form via evolutionarily distinct mechanisms in mammalian skin. Nature · 2026
- Cold Atmospheric Plasma-Activated In Situ Hydrogel Induces Hair Regeneration Via Immune Mi… Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
- Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoim… Cell · 2026
- Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connectiv… Nature communications · 2026
- TGFα is required for hair follicle function during aging and its loss leads to progressive… The Journal of investigative dermatology · 2025
- MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration. Nature communications · 2025
연도별 인용 (2020–2026) · 합계 327
OpenAlex 토픽 ·
Hair Growth and Disorders
Cancer-related Molecular Pathways
melanin and skin pigmentation
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
생쥐 피부의 모발 성장기와 휴지기 동안 전층 피부(full-thickness skin)를 구성하는 세포 유형과 공간적 분포를 단일세포 수준에서 체계적으로 규명하여, 모낭(hair follicle) 항상성 및 분화 기전을 이해하기 위함이다.
【방법】
단일세포 RNA 시퀀싱(single-cell RNA-seq)과 단일분자 RNA FISH 기법을 병용하여 표피·진피·혈관·면역세포를 포괄하는 56가지 세포 유형 및 상태의 유전자 발현 프로파일과 공간적 위치를 매핑하고, 온라인 탐색 도구로 공개하였다.
【주요 결과】
외측모근초(outer root sheath, ORS)는 기질세포와 상호작용 능력이 다른 두 가지 전사학적으로 구별되는 세포군이 혼재되어 구성되며, 내측 모낭층 세포들은 미분화 전구세포에서 분기하여 각각 중간 상태를 거쳐 분화함을 확인하였다.
【임상적 시사점 (성형외과 의사 관점)】
모낭 줄기세포 niche의 세포 다양성과 분화 경로 지도는 모발이식(hair transplantation) 후 생착률 향상, 탈모(alopecia) 치료를 위한 표적세포 선별, 그리고 외측모근초 기반 모낭 재생/배양 기술 개발에 직접적인 분자생물학적 근거를 제공한다. 향후 PRP, exosome, 줄기세포 주입 시술의 작용 기전을 세포 아형 단위로 해석할 수 있는 참조 아틀라스로 활용 가능하다.
Skin homeostasis is orchestrated by dozens of cell types that together direct stem cell renewal, lineage commitment, and differentiation. Here, we use single-cell RNA sequencing and single-molecule RNA FISH to provide a systematic molecular atlas of full-thickness skin, determining gene expression profiles and spatial locations that define 56 cell types and states during hair growth and rest. These findings reveal how the outer root sheath (ORS) and inner hair follicle layers coordinate hair production. We found that the ORS is composed of two intermingling but transcriptionally distinct cell types with differing capacities for interactions with stromal cell types. Inner layer cells branch from transcriptionally uncommitted progenitors, and each lineage differentiation passes through an intermediate state. We also provide an online tool to explore this comprehensive skin cell atlas, including epithelial and stromal cells such as fibroblasts, vascular, and immune cells, to spur further discoveries in skin biology.
【연구 목적】 생쥐 피부의 모발 성장기와 휴지기 동안 전층 피부(full-thickness skin)를 구성하는 세포 유형과 공간적 분포를 단일세포 수준에서 체계적으로 규명하여, 모낭(hair follicle) 항상성 및 분화 기전을 이해하기 위함이다.
APA 7
Joost, S., Annusver, K., Jacob, T., Sun, X., Dalessandri, T., Sivan, U., Sequeira, I., Sandberg, R., & Kasper, M. (2020). The molecular anatomy of mouse skin during hair growth and rest.. Cell stem cell, 26(3), 441-457.e7. https://doi.org/10.1016/j.stem.2020.01.012
Vancouver
Joost S, Annusver K, Jacob T, Sun X, Dalessandri T, Sivan U, et al. The Molecular Anatomy of Mouse Skin during Hair Growth and Rest. Cell stem cell. 2020;26(3):441-457.e7. doi:10.1016/j.stem.2020.01.012
AMA 11
Joost S, Annusver K, Jacob T, Sun X, Dalessandri T, Sivan U, et al. The Molecular Anatomy of Mouse Skin during Hair Growth and Rest. Cell stem cell. 2020;26(3):441-457.e7. doi:10.1016/j.stem.2020.01.012
Chicago
Joost, S., Annusver, K., Jacob, T., Sun, X., Dalessandri, T., Sivan, U., Sequeira, I., Sandberg, R., and Kasper, M.. 2020. "The Molecular Anatomy of Mouse Skin during Hair Growth and Rest." Cell stem cell 26 (3): 441-457.e7. https://doi.org/10.1016/j.stem.2020.01.012
MLA 9
Joost, S., et al. "The Molecular Anatomy of Mouse Skin during Hair Growth and Rest." Cell stem cell, vol. 26, no. 3, 2020, pp. 441-457.e7. doi:10.1016/j.stem.2020.01.012.
PMID
32109378 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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- Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state.
- Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis.
- The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia.
- The dermal sheath: An emerging component of the hair follicle stem cell niche.
- Hair follicle stem cells as a skin-organizing signaling center during adult homeostasis.
- Status of research on the development and regeneration of hair follicles.
- High-resolution single-cell transcriptomics reveals heterogeneity of self-renewing hair follicle ste…
- Aging of hair follicle stem cells and their niches.
- Building and Maintaining the Skin.
- Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview.
- Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue.
- Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration.
- Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal P…
- Restoration of follicular β-catenin signaling by mesenchymal stem cells promotes hair growth in mice…
- VDR is an essential regulator of hair follicle regression through the progression of cell death.
- Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing.
- Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insigh…
- A prenatal skin atlas reveals immune regulation of human skin morphogenesis.
- Molecular and spatial landmarks of early mouse skin development.
같은 제1저자의 인용 많은 논문 (2)
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
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Alopecia areata.
TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
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Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
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Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…
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Alopecia areata: A multifactorial autoimmune condition.
TL;DRVarious genetic and environmental factors that cause autoimmunity are discussed and the immune mechanisms that lead to hair loss in alopecia areata patients are described.
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Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
TL;DRThe first meta-analysis of research on AA is performed by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a to…