A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.

Brian Biehs; Gerrit J.P. Dijkgraaf; Robert Piskol; Bruno Alicke; Soufiane Boumahdi; Franklin Peale; Stephen E. Gould; Frédéric J. de Sauvage

doi:10.1038/s41586-018-0596-y

← 뒤로

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.

✂️ 성형 🏥 중증 🦱 탈모

4/5 보강

Nature 📖 저널 OA 64.1% 2021~2026 2018 Vol.562(7727) p. 429-433 피인용 3회 cited 139 RCR 3.03 Hedgehog Signaling Pathway Studies

TL;DR Treatment of BCC with both vismodegib and a Wnt pathway inhibitor reduced the residual tumour burden and enhanced differentiation and identified a resistance mechanism in which tumour cells evade treatment by adopting an alternative identity that does not rely on the original oncogenic driver for survival.

🔎 핵심 키워드 모낭 모낭 모낭 전체 NER ↓

📑 코퍼스 인용 관계 · 인용됨 3

📑 인용한 논문 (3) ▾

Does Basal Cell Carcinoma Arise from a Precursor Lesion? The Journal of investigative dermatology · 2026
A systematic summary of survival and death signalling during the life of hair follicle ste… Stem cell research & therapy · 2021
AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cel… Nature communications · 2020

연도별 인용 (2018–2025) · 합계 139

OpenAlex 토픽 · Hedgehog Signaling Pathway Studies Cancer and Skin Lesions Tumors and Oncological Cases

Biehs B, Dijkgraaf GJP, Piskol R, Alicke B, Boumahdi S, Peale F

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

이 논문을 인용하기

↓ .bib ↓ .ris

APA Brian Biehs, Gerrit J.P. Dijkgraaf, et al. (2018). A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.. Nature, 562(7727), 429-433. https://doi.org/10.1038/s41586-018-0596-y

MLA Brian Biehs, et al.. "A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.." Nature, vol. 562, no. 7727, 2018, pp. 429-433.

PMID 30297801 ↗

DOI 10.1038/s41586-018-0596-y

Abstract

Despite the efficacy of Hedgehog pathway inhibitors in the treatment of basal cell carcinoma (BCC), residual disease persists in some patients and may contribute to relapse when treatment is discontinued. Here, to study the effect of the Smoothened inhibitor vismodegib on tumour clearance, we have used a Ptch1-Trp53 mouse model of BCC and found that mice treated with vismodegib harbour quiescent residual tumours that regrow upon cessation of treatment. Profiling experiments revealed that residual BCCs initiate a transcriptional program that closely resembles that of stem cells of the interfollicular epidermis and isthmus, whereas untreated BCCs are more similar to the hair follicle bulge. This cell identity switch was enabled by a mostly permissive chromatin state accompanied by rapid Wnt pathway activation and reprogramming of super enhancers to drive activation of key transcription factors involved in cellular identity. Accordingly, treatment of BCC with both vismodegib and a Wnt pathway inhibitor reduced the residual tumour burden and enhanced differentiation. Our study identifies a resistance mechanism in which tumour cells evade treatment by adopting an alternative identity that does not rely on the original oncogenic driver for survival.

추출된 의학 개체 (NER)

해부 모낭 hair follicle 모낭 hair follicle 모낭 hair follicle

전체 NER 표 보기

유형	영어 표현	한국어 / 풀이	출처	등장
해부	`hair follicle`	모낭	dict	1
해부	`hair follicle`	모낭	dict	1
해부	`hair follicle`	모낭	dict	1

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

인용 관계

그래프 OA 노드: 3/3 (100%) · 참조 0편 · 후속 3편

이 논문을 인용한 후속 연구 3

A systematic summary of survival and death signalling during the life of hair follicle stem cells.
2021 Hu XM 외 cited 34 📖
AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinom…
2020 Yao CD 외 cited 3 📖
Does Basal Cell Carcinoma Arise from a Precursor Lesion?
2026 Wong SY 외 📖 unpaywall

🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반

서로 다른 섬유아세포 계통이 피부 발달 및 재생에서 진피 구조를 결정한다.
Nature 2013 Driskell RR 외 cited 1277 📖 OA
성체 다능성 줄기세포로부터의 모낭 형태형성과 재생.
Cell 2001 Oshima H 외 cited 1034 📖 OA
원형 탈모는 세포독성 T 림프구에 의해 유발되며 JAK 억제로 회복된다.
Nature medicine 2014 Xing L 외 cited 938 📖 OA
Sonic hedgehog 신호전달은 모발 발달에 필수적이다.
Current biology : CB 1998 St-Jacques B 외 cited 799 📖 OA
Lgr6는 피부의 모든 세포 계통을 생성하는 모낭 내 줄기세포를 표지한다.
Science (New York, N.Y.) 2010 Snippert HJ 외 cited 797 📖 OA
주기적 진피 BMP 신호전달은 모발 재생 중 줄기세포 활성화를 조절한다.
Nature 2008 Plikus MV 외 cited 753 📖 OA

📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능

Alopecia areata.
Nature reviews. Disease primers 2017 Pratt CH 외 cited 257 📖 OA

TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
Journal of cosmetic dermatology 2021 Nestor MS 외 cited 124 📖 OA

TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
Hair follicle immune privilege and its collapse in alopecia areata.
Experimental dermatology 2020 Bertolini M 외 cited 102 📖 OA

TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…
Alopecia areata: A multifactorial autoimmune condition.
Journal of autoimmunity 2019 Simakou T 외 cited 101 📖 OA

TL;DRVarious genetic and environmental factors that cause autoimmunity are discussed and the immune mechanisms that lead to hair loss in alopecia areata patients are described.
Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development.
Cells 2019 Gentile P 외 cited 84 📖 OA

TL;DRThe significant improvements in intraoperative stem cell approaches, from in vivo models to clinical investigations, are reviewed and the potential regenerative instruments and fun…

관련 도메인