Current use of botulinum neurotoxin in esthetic practice-Clinical guide and review.

[BACKGROUND] Botulinum neurotoxin is one of the most versatile and widely used medical products in the world.

[AIMS] The review's focus is the plastic and dermatologic uses of botulinum neurotoxin currently supported by published data.

[METHODS] Relevant clinical articles regarding botulinum neurotoxin use in plastic surgery, dermatology, and general esthetic literature were searched and reviewed.

[RESULTS] The search yielded 258 studies. Two hundred articles were excluded following title and abstract review. Twenty-one studies were excluded following full-text screening. A total of 37 studies remained and were discussed in this review.

[CONCLUSIONS] Botulinum neurotoxin is widely used for numerous off-label indications from head to toe. Some uses are well documented, and their safety has been demonstrated in controlled trials, yet most remain poorly researched.