Prediction of Ecchymosis and Edema after Rhinoplasty: Changes in Perioperative Inflammation Indixes.

This study aimed to investigate perioperative changes in the systemic immune-inflammation index (SII) and the systemic inflammation response index (SIRI) and their relationship with postoperative edema and ecchymosis following rhinoplasty. This study was approved by the Ethics Committee of Tokat Gaziosmanpasa University (2024/No: 24-KAEK-185). This prospective observational study included 94 patients who underwent open rhinoplasty under general anesthesia. The study evaluated the relationship between changes in SII (ΔSII) and SIRI (ΔSIRI), calculated from hemogram tests performed 2 h before and 2 h after surgery, and the severity of periorbital edema and ecchymosis in the early and late postoperative periods. The ΔSII value was significantly higher in the severe edema group compared with the minimal/moderate edema group in both the early and late postoperative periods ( = 0.003,  = 0.03, respectively). In addition, ΔSII was significantly higher in the severe ecchymosis group than in the minimal/moderate ecchymosis group in the early postoperative period ( = 0.03). The ΔSIRI value was significantly higher in the severe edema and ecchymosis groups compared with the minimal/moderate groups in the early postoperative period ( = 0.04,  = 0.01, respectively). This study demonstrated a significant association between perioperative changes in SII and SIRI and the severity of periorbital edema and ecchymosis following open rhinoplasty. These indices may serve as valuable markers for predicting the extent of postoperative inflammatory responses in rhinoplasty patients.