Use of Isotretinoin in Rhinoplasty: A Literature Review.

This literature review explores the role of isotretinoin as an adjunct therapy in rhinoplasty, particularly in patients with thick nasal skin. Thick skin, often associated with excessive sebaceous activity, can obscure surgical refinements and compromise aesthetic outcomes. Isotretinoin, known for its ability to reduce sebaceous gland activity, improve skin elasticity, and regulate keratinization, has been investigated for its potential to enhance postoperative results in rhinoplasty patients. This review synthesizes existing studies, including randomized controlled trials (RCTs), retrospective analysis, and ultrasonographic assessments, to evaluate the effectiveness and safety of isotretinoin in this context.