Cryoanalgesic versus EMLA® cream to reduced pain during analgesic injection in upper eyelid surgery: a randomized trial.

[INTRODUCTION] Eyelid surgery under local anesthesia is a common procedure in ophthalmology. The most painful part is usually injecting local anesthesia. Decreased sensation from the very sensitive eyelid skin before injection is one of the few methods to relieve this stressful condition. In this study, we compared the use of the aesthetic property of cooling (cryoanalgesic) with topical EMLA® cream preparation before local anesthetic injection on the eyelid.

[METHODS] Thirty patients aged 47-81 years (mean = 65.6, SD = 9.75) undergoing upper eyelid blepharoplasty or levator advancement surgery were enrolled. Each subject's upper eyelid was randomly allocated by a computer-generated randomization sequence to an EMLA® cream or cryoanalgesic group before injecting local anesthetic. Pain monitoring was performed subjectively and objectively using a visual analog scale (VAS). Results were analyzed using the paired t-test.

[RESULTS] No statistical difference was found in VAS score between the EMLA® cream (mean = 5.9) and cryoanalgesic groups (mean = 5.67) (-value 0.5999).

[CONCLUSION] Topical EMLA® cream and cryoanalgesic have no difference in pain score from anesthetic infiltration during eyelid surgery.