Clinical and surgical outcomes of virginal breast hypertrophy (VBH) in adolescent females: a systematic review of case reports.

[BACKGROUND] The rare medical condition known as Virginal Breast Hypertrophy causes massive adolescent breast growth that leads to the important health problems with social implications. This systematic review examines treatment procedures and psychological effects along with identifying remaining knowledge gaps regarding this disorder.

[METHODS] The research team executed a PRISMA-based literature search covering cases from the year 1934 to 2023, and analyzed 69 cases of VBH. The analysis included information about symptoms at diagnosis and treatment methods along with the recurrence rates and details about psychological elements. The study included patients who experienced juvenile breast hypertrophy during adolescence.

[RESULTS] VBH typically presented with rapid bilateral breast enlargement (91.3%) and psychological distress (71%). The mean age of onset was 11.27 years, with disease progression averaging 10 months. Menarche was documented in 43.75%. Subcutaneous mastectomy showed the lowest recurrence rate (5.8%), while reduction mammoplasty had a recurrence rate of 44.7%. Medical treatments (e.g., tamoxifen, bromocriptine) showed variable outcomes, with most patients exhibiting no hormonal abnormalities.

[CONCLUSIONS] Among breast cancer treatments subcutaneous mastectomy stands as the most successful method that results in few recurrences. Documentation of psychological distress created by VBH demands collaborative care strategies and extensive investigations into genetic molecular influences.