Genotoxicity of human mammary lipid.
Abstract
We tested the proposition that human mammary lipid contains mutagenic/genotoxic agents that could cause DNA damage in adjacent epithelial cells. Lipid samples from breast tissue surgically removed from 40 women undergoing elective reduction mammoplasty were extracted by a solid-phase procedure. Mutagenicity was observed in Salmonella typhimurium TA98 and TA1538 in 16 of 40 (40%) extracts assayed with rat-liver S9, but not in its absence. No mutagenicity was seen in S. typhimurium TA100 or Escherichia coli WP2uvrA(pKM101). Bacterial mutagenicity correlated with micronucleus-forming activity in a metabolically competent mammalian cell line (MCL-5). This genotoxic activity merits further investigation in relation to the etiology of breast cancer.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | mammary
|
유방 | dict | 2 | |
| 해부 | breast
|
유방 | dict | 2 | |
| 시술 | reduction mammoplasty
|
유방성형술 | dict | 1 | |
| 해부 | DNA
|
scispacy | 1 | ||
| 해부 | epithelial cells
|
scispacy | 1 | ||
| 해부 | extracts
|
scispacy | 1 | ||
| 해부 | mammalian cell line
|
scispacy | 1 | ||
| 해부 | MCL-5
|
scispacy | 1 | ||
| 약물 | typhimurium
|
scispacy | 1 | ||
| 약물 | TA1538
|
scispacy | 1 | ||
| 약물 | S. typhimurium TA100
|
scispacy | 1 | ||
| 약물 | micronucleus-forming
|
scispacy | 1 | ||
| 질환 | breast cancer
|
C0006142
Malignant neoplasm of breast
|
scispacy | 1 | |
| 질환 | breast tissue
|
scispacy | 1 | ||
| 기타 | human mammary lipid
|
scispacy | 1 | ||
| 기타 | women
|
scispacy | 1 | ||
| 기타 | rat-liver S9
|
scispacy | 1 | ||
| 기타 | Escherichia coli
|
scispacy | 1 |
MeSH Terms
Adipose Tissue; Adolescent; Adult; Animals; Biotransformation; Breast; Breast Neoplasms; Carcinogens, Environmental; Cell Line; Escherichia coli; Female; Humans; Lipid Peroxidation; Lipids; Male; Malondialdehyde; Micronucleus Tests; Microsomes, Liver; Middle Aged; Mutagenicity Tests; Oils; Oxidation-Reduction; Rats; Rats, Wistar; Salmonella typhimurium; Solubility
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