[Silicone implants and breast cancer: real or fictitious problem? A case report and review of the literature].

Le Journal medical libanais. The Lebanese medical journal 1994 Vol.42(1) p. 32-6

Daher M, Rizkallah P, Abdel-Hak E

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Abstract

We present a case of breast cancer 9 years after subcutaneous mastectomy for bilateral phylloid tumor with silicone implants. The patient had a stage III adenocarcinoma (T4 N1 M0) at diagnosis; a modified radical mastectomy was done, followed by radiotherapy and chemotherapy. Later on, Tamoxifen was prescribed (positive hormone receptors). Reviewing the literature about this subject in a context of a moratorium of the Food and Drug Administration (FDA) in the United States recommending suspension of silicone breast implantation, we can propose several conclusions: Previous and recent studies did not show any direct relation between cancer and silicone implants for augmentation mammoplasty; on the contrary, a lower incidence of breast cancer is noted. Breast cancer incidence with silicone implants seems to be higher with reconstructive mammoplasty after mastectomy for benign disease (fibrocystic disease, dysplasia, phylloid tumor), or prophylactic reason, or malignancy (carcinoma in situ, lobular and multifocal carcinoma, early breast cancer...). This can be related to recurrence or cancer development on residual breast tissue. Breast cancer with silicone implants is of poorer prognosis because of the later diagnosis of the disease.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
해부 breast 유방 dict 8
시술 augmentation mammoplasty 유방성형술 dict 1
시술 mammoplasty 유방성형술 dict 1
해부 subcutaneous 피하조직 dict 1
합병증 fibrocystic disease scispacy 1
합병증 dysplasia scispacy 1
약물 Silicone C0037114
silicones
scispacy 1
약물 Tamoxifen C0039286
tamoxifen
scispacy 1
질환 breast cancer C0006142
Malignant neoplasm of breast
scispacy 1
질환 phylloid tumor scispacy 1
질환 adenocarcinoma C0001418
Adenocarcinoma
scispacy 1
질환 silicone breast scispacy 1
질환 cancer C0006826
Malignant Neoplasms
scispacy 1
질환 benign disease C0016034
Breast Fibrocystic Disease
scispacy 1
질환 fibrocystic disease C0010674
Cystic Fibrosis
scispacy 1
질환 dysplasia C0334044
Dysplasia
scispacy 1
질환 malignancy C0006826
Malignant Neoplasms
scispacy 1
질환 carcinoma C0007097
Carcinoma
scispacy 1
질환 lobular scispacy 1
질환 breast tissue scispacy 1
기타 bilateral phylloid tumor scispacy 1
기타 patient scispacy 1

MeSH Terms

Adenocarcinoma; Adult; Breast Implants; Breast Neoplasms; Female; Humans; Mastectomy, Subcutaneous; Neoplasms, Second Primary; Phyllodes Tumor; Silicones

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