Selective augmentation of stem cell populations in structural fat grafts for maxillofacial surgery.

PloS one 2014 Vol.9(11) p. e110796

Clauser L, Ferroni L, Gardin C, Tieghi R, Galiè M, Elia G, Piattelli A, Pinton P, Bressan E, Zavan B

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Abstract

Structural fat grafting utilizes the centrifugation of liposuction aspirates to create a graded density of adipose tissue. This study was performed to qualitatively investigate the effects of centrifugation on stem cells present in adipose tissue. Liposuction aspirates were obtained from healthy donors and either not centrifuged or centrifuged at 1,800 rpm for 3 minutes. The obtained fat volumes were divided into three layers and then analyzed. The results demonstrate that centrifugation induces a different distribution of stem cells in the three layers. The high-density layer displays the highest expression of mesenchymal stem cell and endothelial markers. The low-density layer exhibits an enrichment of multipotent stem cells. We conclude that appropriate centrifugation concentrates stem cells. This finding may influence the clinical practice of liposuction aspirate centrifugation and enhance graft uptake.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 liposuction 지방흡입 dict 3
해부 stem cell scispacy 1
해부 fat grafts scispacy 1
해부 maxillofacial scispacy 1
해부 fat scispacy 1
해부 adipose tissue scispacy 1
해부 stem cells scispacy 1
해부 mesenchymal stem cell scispacy 1
해부 endothelial scispacy 1
해부 multipotent stem cells scispacy 1
해부 graft scispacy 1
합병증 high-density layer scispacy 1
합병증 low-density layer scispacy 1
합병증 liposuction aspirate scispacy 1
질환 layers scispacy 1
기타 donors scispacy 1

MeSH Terms

Adipose Tissue; Adult; Centrifugation; Female; Humans; Lipectomy; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Surgery, Oral; Tissue Scaffolds; Young Adult

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