Bone Resorption of Hyaluronic Acid Fillers Injection Induced in Chin Augmentation: A Retrospective Study.

[BACKGROUND] Among several skin fillers developed in recent decades, hyaluronic acid (HA) is a widely used filler for face contouring and is generally believed to be safe, long-lasting, not immunogenic, and cost-effective. However, early and delayed complications can also occur following HA filler injection. Unfortunately, there have been reports of HA-related bone erosion in the chin area without clear scientific data regarding its existence and incidence. Herein, we described the clinical characteristics of HA injection-induced bone resorption in chin augmentation in the south of China.

[METHODS] A total of 8 patients consisting of males and females who received hyaluronic acid injection for chin augmentation and rejuvenation were enrolled in the study. The authors retrospectively compared the CT scans of patients with mentum augmentation using HA. The bone resorption area was measured as the average length, width, and depth. Injection volume, the number of injections, complications and the measurement data of bone resorption were also recorded.

[RESULTS] From January 2023 to January 2024, 8 patients were recruited. The postoperative CT scan revealed pronounced deep concavities in the incisive fossa, with no evidence of periapical lesions. No patients complained of any instances of infection or hematoma following the injection, and no clinical symptoms were observed.

[CONCLUSIONS] Bone resorption from the chin after HA filler injection can occur. To draw a clear conclusion, more adapted and well-designed clinical trials are needed to assess the emergence of this phenomenon.