Aquagenic Palmoplanta keratoderma: Response to Topical Pimecrolimus and Literature Review.

Aquagenic palmoplantar keratoderma (APK) is a rare skin disease characterized by temporary papules and macerated plaques triggered by contact with water. Failure to receive timely and proper treatment may seriously damage the patient's daily life. The precise pathogenesis of APK (Aquagenic Palmoplantar Keratoderma) remains poorly understood, and safe and efficacious therapeutic options are currently lacking. The conventional therapy mainly involves topical application of aluminum chloride, followed by botulinum toxin injection, topical corticosteroids, topical salicylic acid, barrier agents, and oral antihistamines. This case report presents an APK patient who showed improvement after tw1o months of treatment with pimecrolimus cream, slight symptom recurrence following water exposure or sweating.