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Longitudinal, Multi-Cycle Evaluation of Passive Function Improvement in People with Arm Spasticity Treated with Botulinum Toxin A.

Toxins 2026 Vol.18(1)

Ashford SA, Buchwald K, Fheodoroff K, Jacinto J, Narayanan A, Siegert RJ, Hannes C, Turner-Stokes L

PMC 전문 ↗ 원문 ↗ DOI ↗

관련 도메인

보툴리눔독소 주사 Botulinum Toxin Injection

Abstract

Improvement in passive function (i.e., ease of caring for a limb) is a common goal for treatment of spasticity in the arm with botulinum toxin. A large international, observational, 2-year longitudinal study (ULIS-III, N = 953) was conducted in real-life practice. This original secondary analysis examines whether improvement in passive function goals were met over repeated injection cycles. We report changes by cycle measured by the Passive Function sub-scale of the Arm Activity measure (ArmA-PF) and examine predictors of improvement and injection occurrence. Inclusion in this analysis was based on passive function being selected as a primary or secondary goal for one or more cycle of treatment ( = 542/953). Goals were assessed at the start and end of each cycle using the Goal Attainment Test score and the ArmA-PF. Over all cycles of treatment, goals were set for 1641/2187 injections (75.0%) and achieved in 1250 (76.2%). Significant improvements in ArmA-PF score were identified for at least six cycles ( < 0.001) with evidence of cumulative benefit over successive cycles. This occurred regardless of patient-related baseline characteristics, with the possible exception of some relationship with injection localization techniques. In conclusion, repeated botulinum toxin injections provide significant improvement in passive function, which was sustained over repeated cycles of treatment.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 3
약물 Arm scispacy 1
질환 Spasticity C0026838
Muscle Spasticity
 scispacy 1
질환 Botulinum Toxin A. C0006055
Botulinum Toxins
 scispacy 1
기타 People scispacy 1
기타 Arm scispacy 1
기타 Botulinum Toxin A. scispacy 1

MeSH Terms

Muscle Spasticity; Humans; Botulinum Toxins, Type A; Male; Longitudinal Studies; Female; Middle Aged; Arm; Adult; Neuromuscular Agents; Aged; Treatment Outcome; Young Adult

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이 논문이 참조한 문헌 43

외부 PMID 30건 (DB 미수집)

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필러 주입술 (21) 안검성형술 (14) 유방 (10) 안면거상술 (10) 지방흡입 (9) 코성형술 (8) 히알루론산 (7) 유방성형술 (6)

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