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Botulinum Toxin Treatment of Notalgia Paresthetica-A Critical Review and Update.

Toxins 2026 Vol.18(1)

Tohidian AG, Etemadmoghadam S, Jabbari B

PMC 전문 ↗ 원문 ↗ DOI ↗

관련 도메인

보툴리눔독소 주사 Botulinum Toxin Injection

Abstract

Notalgia paresthetica is a condition characterized by pruritus and pain in the upper back, often associated with skin discoloration in the same area. Through Medline, Google Scholar, and Scopus search engines, we identified reports of eight clinical studies (published up to 1 December 2025) on the subject of botulinum neurotoxin therapy for Notalgia Paresthetica (NP). Only one of the eight studies was double-blind and placebo-controlled. The search strategy included only articles published in English and Spanish, and articles providing basic information such as the type of study, type and dose of the toxin, and results of the treatment. Articles not in English or Spanish, review articles, and articles failing basic information were excluded. A total of 34 patients were found across all studies. The injected toxin in the open-label studies was onabotulinumtoxin-A (Botox), whereas in the blinded study, the investigators used incobotulinumtoxinA (Xeomin). All open-label studies reported improvement in pruritus, and some reported improvement in pain, whereas the blinded study failed to do so. The possible reasons for this discrepancy between the blinded and the open-label studies are discussed. There is a need for double-blind, placebo-controlled studies with a larger number of patients, preferably using the same neurotoxin that has suggested efficacy in the open-label studies. The novelty of this review is that it represents a comprehensive and critical literature assessment on this topic and that it includes data not present in the previous reviews of this subject.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 1
시술 onabotulinumtoxin 보툴리눔독소 주사 dict 1
시술 botox 보툴리눔독소 주사 dict 1
시술 xeomin 보툴리눔독소 주사 dict 1
해부 upper back scispacy 1
해부 skin scispacy 1
합병증 paresthetica scispacy 1
약물 incobotulinumtoxinA C2930113
incobotulinumtoxinA
 scispacy 1
질환 Notalgia C0004604
Back Pain
 scispacy 1
질환 Notalgia paresthetica C0457010
Notalgia paresthetica
 scispacy 1
질환 pruritus C0033774
Pruritus
 scispacy 1
질환 pain C0030193
Pain
 scispacy 1
질환 skin discoloration C0151907
Discoloration of skin
 scispacy 1
기타 botulinum neurotoxin scispacy 1
기타 patients scispacy 1
기타 neurotoxin scispacy 1

MeSH Terms

Humans; Botulinum Toxins, Type A; Paresthesia; Pruritus; Treatment Outcome

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이 논문이 참조한 문헌 44

외부 PMID 30건 (DB 미수집)

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