A herbal approach to diabetic cardiomyopathy: moringa, ginger, and garlic unveiled.

[OBJECTIVE] Chronic inflammation contributes to myocardial complications in diabetes, marked by tissue fibrosis, necrosis, and apoptosis. and have individually demonstrated efficacy in diabetes management. In this study, it is hypothesised that a combination of these herbs in a polyherbal formulation would protect against diabetic cardiomyopathy.

[MATERIALS AND METHODS] Diabetes was induced in male Sprague Dawley rats using strepetozotocin at a single dose of (55 mg/kg of body weight, in citrate buffer. Polyherbal formulation was administred as a treatment for 8 weeks.

[UNLABELLED] Rats receiving treatment with polyherbal formulation showed decreased blood glucose, plasma creatinine, Blood Urea Nitrogen, Creatine kinase- myocardial band, lactate dehydrogenase, aspartate aminotransferase, Troponin-I, NADPH oxidase 4, and Ras-related C3 botulinum toxin substrate-1. In contrast, Superoxide dismutase, catalase, and glutathione enzyme activities were increased.

[CONCLUSION] Thus, a polyherbal formulation containing herbs was able to attenuate the progression of diabetes mellitus and diabetic cardiomyopathy.