Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children.
Abstract
[WHAT IS KNOWN] Botulinum toxin (BoNT) causes muscle relaxation by inhibiting acetylcholine release from presynaptic motor neurons at the neuromuscular junction.
[WHAT IS NEW] In children with achalasia, BoNT can be considered only in patients in whom rapid weight gain is important to improve surgical outcomes. BoNT has been suggested for treating cricopharyngeal achalasia and delayed gastric emptying. Anal achalasia and constipation after Hirschsprung disease corrective surgery are very promising indications for BoNT use. In selected children with resistant type of functional constipation and chronic anal fissure, BoNT is a viable option for treating.
[WHAT IS NEW] In children with achalasia, BoNT can be considered only in patients in whom rapid weight gain is important to improve surgical outcomes. BoNT has been suggested for treating cricopharyngeal achalasia and delayed gastric emptying. Anal achalasia and constipation after Hirschsprung disease corrective surgery are very promising indications for BoNT use. In selected children with resistant type of functional constipation and chronic anal fissure, BoNT is a viable option for treating.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | botulinum toxin
|
보툴리눔독소 주사 | dict | 2 | |
| 해부 | muscle
|
scispacy | 1 | ||
| 해부 | acetylcholine
|
scispacy | 1 | ||
| 해부 | neuromuscular
|
scispacy | 1 | ||
| 해부 | gastric
|
scispacy | 1 | ||
| 합병증 | achalasia
|
scispacy | 1 | ||
| 합병증 | anal fissure
|
scispacy | 1 | ||
| 약물 | BoNT
→ Botulinum toxin
|
C0006055
Botulinum Toxins
|
scispacy | 1 | |
| 약물 | acetylcholine
|
C0001041
acetylcholine
|
scispacy | 1 | |
| 약물 | [WHAT IS KNOWN] Botulinum toxin
|
scispacy | 1 | ||
| 약물 | [WHAT IS NEW] In
|
scispacy | 1 | ||
| 질환 | gastrointestinal disorders
|
C0017178
Gastrointestinal Diseases
|
scispacy | 1 | |
| 질환 | achalasia
|
C0014848
Esophageal Achalasia
|
scispacy | 1 | |
| 질환 | weight gain
|
C0043094
Weight Gain
|
scispacy | 1 | |
| 질환 | Anal achalasia
|
scispacy | 1 | ||
| 질환 | constipation
|
C0009806
Constipation
|
scispacy | 1 | |
| 질환 | Hirschsprung disease
|
C0019569
Hirschsprung Disease
|
scispacy | 1 | |
| 질환 | chronic anal fissure
|
C0349071
Chronic anal fissure
|
scispacy | 1 | |
| 질환 | gastrointestinal
|
scispacy | 1 | ||
| 기타 | children
|
scispacy | 1 | ||
| 기타 | BoNT
→ Botulinum toxin
|
scispacy | 1 | ||
| 기타 | patients
|
scispacy | 1 |
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