Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?
Abstract
Driven by the clinical success of botulinum toxin serotype A (BoNT/A) and the need for improved chronic pain management, researchers attempted to develop re-designed botulinum toxin (BoNT)-based molecules as novel analgesics. Various recombinant protein expression strategies including retargeted binding domains, and chimeric toxins combining different serotypes were tested to improve BoNT/A therapeutic safety margin and expand its efficacy. The aim of this review is to re-evaluate the current design strategies for recombinant BoNT-based molecules for pain treatment, compares their analgesic profile against the native BoNT/A, as well as to discuss the main strengths and potential weaknesses of reported approaches.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | botulinum toxin
|
보툴리눔독소 주사 | dict | 3 | |
| 질환 | pain
|
C0030193
Pain
|
scispacy | 1 | |
| 기타 | BoNT/A
→ botulinum toxin serotype A
|
scispacy | 1 |
MeSH Terms
Humans; Botulinum Toxins, Type A; Animals; Pain; Analgesics; Recombinant Proteins
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