The S-Nitrosylation of Septin2 (SNO-Septin2) axis: A novel potential therapeutic target for treating aneurysms and dissection.
Abstract
Aortic aneurysm and aortic dissection (AAD) are severe life-threatening cardiovascular disorders for which no approved pharmaceutical therapies are currently available. Protein S-nitrosylation (SNO) is a typical redox-dependent posttranslational modification whose role in AAD has yet to be described. Recently, Zhang et al. revealed for the first time that SNO modification of macrophage cytoskeletal protein septin2 promotes vascular inflammation and extracellular matrix degradation in aortic aneurysm. Mechanically, the TIAM1-RAC1(T lymphoma invasion and metastasis-inducing protein 1-Ras-related C3 botulinum toxin substrate 1) axis participates in the progression of AAD induced with S-nitrosylated septin2. More importantly, developing R-ketorolac and NSC23766 compounds that specifically target the TIAM1-RAC1 pathway may be new a potential strategy for alleviating AAD.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | botulinum toxin
|
보툴리눔독소 주사 | dict | 1 | |
| 해부 | extracellular matrix
|
scispacy | 1 | ||
| 약물 | SNO
→ S-nitrosylation
|
scispacy | 1 | ||
| 약물 | NSC23766
|
scispacy | 1 | ||
| 질환 | aneurysms
|
C0002940
Aneurysm
|
scispacy | 1 | |
| 질환 | Aortic aneurysm
|
C0003486
Aortic Aneurysm
|
scispacy | 1 | |
| 질환 | cardiovascular disorders
|
C0007222
Cardiovascular Diseases
|
scispacy | 1 | |
| 질환 | inflammation
|
C0021368
Inflammation
|
scispacy | 1 | |
| 질환 | TIAM1-RAC1(T lymphoma
|
scispacy | 1 | ||
| 질환 | lymphoma
|
scispacy | 1 | ||
| 기타 | Septin2
|
scispacy | 1 | ||
| 기타 | SNO-Septin2
|
scispacy | 1 | ||
| 기타 | redox-dependent
|
scispacy | 1 | ||
| 기타 | macrophage cytoskeletal protein septin2
|
scispacy | 1 | ||
| 기타 | vascular
|
scispacy | 1 | ||
| 기타 | metastasis-inducing protein 1-Ras-related C3 botulinum toxin substrate 1
|
scispacy | 1 |
MeSH Terms
Animals; Humans; Aortic Aneurysm; Aortic Dissection; Molecular Targeted Therapy; Protein Processing, Post-Translational; rac1 GTP-Binding Protein; Septins; Signal Transduction; T-Lymphoma Invasion and Metastasis-inducing Protein 1
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