Long-pulsed Nd: YAG laser (1064 nm) versus intralesional botulinum toxin type (A) in acne vulgaris therapy: a split face study.

[BACKGROUND] Acne can be considered more than a cosmetic concern due to its large impact on patients' quality of life. There are various therapeutic options for inflammatory acne, but inconvenience and undesirable side effects prompted a search for more acceptable treatments. This study aimed to compare the clinical efficacy and safety of long-pulsed Nd: YAG laser 1064 nm versus intralesional botulinum toxin type-A (BTX-A) in inflammatory acne therapy.

[METHODS] A prospective randomized split-face comparative study involved 30 patients with inflammatory acne. Each patient received long-pulsed Nd: YAG 1064 nm laser on one side, and intralesional BTX-A on the other side, monthly until improvement or maximum three sessions. Cases were assessed by acne lesions counting and grading of severity by Investigator's Global Assessment of acne (IGAs) at baseline, each session, and after 3 months follow-up.

[RESULTS] A highly statistically significant improvement in lesions count and IGAs for both sides was observed, with statistically non-significant difference between both sides at end of treatment sessions. While, after 3 months follow-up, there was a more significant improvement at laser side.

[CONCLUSION] Both long-pulsed Nd: YAG laser 1064 nm and intralesional BTX-A are safe and effective for acne therapy. Nd-YAG laser has a more prolonged efficacy and lower recurrence rate than intralesional BTX-A.