The efficacy and complications of a new technique of Abobotulinum-toxin A (Dysport) injection in patients with glabellar lines.

[BACKGROUND] Abobotulinum- toxin A is used extensively for the treatment of frown (glabellar) lines.

[AIMS] The aim of this study was to evaluate the efficacy and complications of a new injection technique and to assess the amount of satisfaction in patients with the frown lines.

[METHODS] This cross-sectional study was conducted in 104 patients with moderate-to-severe glabellar lines. In the new technique by reassessing the responsible anatomic muscles of wrinkles, we tried to modify the injection technique of Abobotulinum-toxin A to yield more favorable results. The range and severity of frown lines were assessed by a 4-score test and a photograph taken before and 2 weeks after the injection. Patients were followed up to 180 days after injection.

[RESULTS] The response time of 87.5% of patients was within the first 48 hours and the remaining 12.5% showed the symptoms within the first week after injection. At 30 days after injection, the frown lines had disappeared in 88.5% of patients in static mode and 85.6% in mechanic mode. Maximum injection durability in the first 3, 4, and 6 months after injection was 82%, 52%, and 38%, respectively. The amount of complete satisfaction after 3 months was reported to be 86.5%.

[CONCLUSIONS] This study indicated that the new injection technique of Abobotulinum-toxin A could be beneficial in the treatment of frown lines with more satisfactory results, especially in those patients who were not contented with the present conventional method.