Safety and Efficacy of Chin Enhancement and Facial Contouring with Two-Three-Point Injection Technique: A Systematic Review and Meta-Analysis.

Aesthetic plastic surgery 2026

Milanifard M, Hashemloo A

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Abstract

[BACKGROUND AND AIM] The present study aimed to evaluate the effectiveness of the two-three-point injection technique using hyaluronic acid fillers to increase chin volume.

[METHOD] The present study included three RCT and three cohort studies of international databases, PubMed, Scopus, Web of Science, and Embase using relevant keywords until June 2025. The statistical analysis was performed with Stata/MP.v17 as fixed or random effect models.

[RESULTS] The GAIS responder rate for chin enhancement of HA filler with two-three-point injection technique was 94% (ES: 0.94; P < 0.001; 95% CI 0.92, 0.97). Common ISRs were firmness (ES: 91%; 95% CI 88-94%) and swelling (ES: 87%; 95% CI 84-90%). The overall rate of adverse events was estimated to be 7.92% (ES: 7.92%; 95% CI 6.31-9.53%).

[CONCLUSION] High efficacy and acceptable safety were evident for the two-three-point injection technique for HA filler injection for the chin enhancement.

[LEVEL OF EVIDENCE V] This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 ha filler 필러 주입술 dict 2
재료 ha 히알루론산 dict 2
시술 facial contouring 안면윤곽술 dict 1
재료 hyaluronic acid 히알루론산 dict 1

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