Assessing healing of periapical pathologies by platelet-rich fibrin: A clinical study.

One of the on-going clinical challenges in endodontic microsurgery is the regeneration of massive periapical lesions. Hence, a Forty patients participated in this randomized controlled clinical experiment to see how well platelet-rich fibrin (PRF) worked as a scaffold for regeneration in comparison to the body's inherent ability to mend blood clots. The decrease in lesion volume, pain ratings, and the repair of soft tissues were evaluated at 6 and 12 months by CBCT. PRF demonstrated a much higher rate of bone regeneration (85.2% vs. 64.8%, p < 0.001) and reduced levels of post-operative discomfort on days 1 and 3. Thus, we show that PRF is an inexpensive and easy way to improve the predictability of recovery after periapical surgery.