A comparative study of microsurgery and gamma knife radiosurgery in vestibular schwannoma evaluating tumor control and functional outcome.

[BACKGROUND] Both stereotactic radiosurgery () and microsurgical resection () are available as treatment options for sporadic vestibular schwannoma (VS). There are very few direct comparative studies comparing both treatment modalities in large cohorts allowing detailed subgroup analysis. This present study aimed to compare the nuances in the treatment of VS by and in 2 highly specialized neurosurgical centers.

[METHODS] This is a retrospective bicentric cohort study. Data from patients treated between 2005 and 2011 were collected retrospectively. Recurrence-free survival (RFS) was assessed radiographically by contrast-enhanced magnetic resonance imaging.

[RESULTS] The study population included = 901 patients with a mean follow-up of 7 years. Overall, the incidence of recurrence was 7% after , and 11% after with superior tumor control in in the Kaplan-Meier-analysis ( = 0.031). In small tumors (Koos I and II), tumor control was equivalent in both treatment arms. In large VS (Koos III and IV), however, RFS was superior in . The extent of resection correlated with RFS ( < .001). Facial and hearing deterioration was similar in both treatment arms in small VS, but more pronounced in of large VS. Tinnitus, vertigo, imbalance, and trigeminal symptoms were more often improved by than .

[CONCLUSIONS] can achieve similar tumor control compared to in smaller VS (Koos I and II)-with similar postinterventional morbidities. In large VS (Koos III and IV), long-term tumor control of is inferior to . Based on these results, we suggest that if combination therapy is chosen, the residual tumor should not exceed the size of Koos II.