CO-TOLMS for laryngeal cancer in the elderly, pushing the boundaries of partial laryngectomy.

Oral oncology 2022 Vol.134() p. 106088

Vilaseca I, Xavier Avilés-Jurado F, Lehrer E, Valduvieco I, Baste N, Delia Ramírez R, Miguel Costa J, Medrano-Martorell S, Muxí Á, Castillo P, Alós L, Bernal-Sprekelsen M

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Abstract

[INTRODUCTION] CO transoral laser microsurgery (CO-TOLMS) has pushed the indications of partial surgery of the larynx regardless the age of the patient.

[OBJECTIVE] To evaluate the complications and the oncologic and functional outcomes of CO-TOLMS in patients older and younger than 70 years.

[METHODS] Retrospective analysis of 1244 consecutive laryngeal carcinomas treated with CO-TOLMS. Complications, length of hospitalization, functional and survival outcomes were evaluated.

[RESULTS] The mean age was 64.2 ± 11.1 years (20-96). Four hundred and sixteen patients were older than 70 years and 104 older than 80 years. The main location was the glottis (912), followed by the supraglottis (332). There were no differences in pT classification between the age groups. No differences were observed in voice outcomes. A higher rate of signs of aspiration at the glottic location was observed for those older than 70 years (2.1 % vs 5 %, p = 0.027). The need for definitive gastrostomy in supraglottic tumours was higher in those older than 70 years (0 % vs 6.5 %, p: 0.001). In the glottis, no differences in tracheostomy or gastrostomy rates were observed. Five-year overall survival was lower in the older than 70 years. No differences in disease-specific survival were observed in early stages for both locations, but a lower survival was observed in stage III glottic cancer for the older than 70 years.

[CONCLUSIONS] CO-TOLMS is a valid treatment for laryngeal carcinomas in the elderly, with a reduced number of complications and good functional and oncologic outcomes.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 microsurgery 미세수술 dict 1
해부 larynx scispacy 1
해부 supraglottis scispacy 1
합병증 glottic scispacy 1
합병증 glottis scispacy 1
약물 [OBJECTIVE] scispacy 1
약물 [CONCLUSIONS] scispacy 1
약물 [INTRODUCTION] CO scispacy 1
질환 stage III glottic cancer scispacy 1
질환 laryngeal cancer C0007107
Malignant neoplasm of larynx
scispacy 1
질환 laryngeal carcinomas C0595989
Carcinoma of larynx
scispacy 1
질환 glottis C0017681
glottis
scispacy 1
질환 supraglottic tumours scispacy 1
질환 glottic cancer C0740083
Carcinoma of glottis
scispacy 1
질환 a reduced number C4086785
Reduced Number
scispacy 1
기타 patient scispacy 1
기타 patients scispacy 1

MeSH Terms

Aged; Carbon Dioxide; Carcinoma, Squamous Cell; Glottis; Humans; Laryngeal Neoplasms; Laryngectomy; Laser Therapy; Middle Aged; Neoplasm Staging; Retrospective Studies; Treatment Outcome

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