Models for Implant-Induced Capsular Contracture Post Breast Cancer Surgery.
Abstract
Capsular contracture is a painful deformation of scar-tissue that may form around an implant in post-breast cancer reconstruction or cosmetic surgery. Inflammation due to surgical trauma or contamination in the tissue around the implant could account for recruitment of immune cells, and transdifferentiation of resident fibroblasts into cells that deposit abnormally thick collagen. Here we examine this hypothesis using a mathematical model for interacting macrophages, fibroblasts, myofibroblasts, and collagen. Our model demonstrates that cellular response can, together with inflammatory cell recruitment, account for prognoses.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | breast
|
유방 | dict | 2 | |
| 합병증 | capsular contracture
|
피막구축 | dict | 2 | |
| 해부 | scar-tissue
|
scispacy | 1 | ||
| 해부 | tissue
|
scispacy | 1 | ||
| 해부 | immune cells
|
scispacy | 1 | ||
| 해부 | fibroblasts
|
scispacy | 1 | ||
| 해부 | cells
|
scispacy | 1 | ||
| 해부 | macrophages
|
scispacy | 1 | ||
| 해부 | myofibroblasts
|
scispacy | 1 | ||
| 해부 | cellular
|
scispacy | 1 | ||
| 해부 | cell
|
scispacy | 1 | ||
| 질환 | Breast Cancer
|
C0006142
Malignant neoplasm of breast
|
scispacy | 1 | |
| 질환 | deformation of scar-tissue that
|
scispacy | 1 | ||
| 질환 | post-breast cancer
|
scispacy | 1 | ||
| 질환 | Inflammation
|
C0021368
Inflammation
|
scispacy | 1 | |
| 질환 | trauma
|
C0043251
Wounds and Injuries
|
scispacy | 1 | |
| 기타 | collagen
|
scispacy | 1 |
MeSH Terms
Humans; Female; Breast Neoplasms; Breast Implants; Mathematical Concepts; Models, Biological; Collagen; Contracture
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